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Association of Trig...
Association of Triglyceride-Glucose Index With Cognitive Function and Brain Atrophy : A Population-Based Study
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Tian, Na (författare)
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Song, Lin (författare)
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Hou, Tingting (författare)
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Fa, Wenxin (författare)
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Dong, Yi (författare)
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Liu, Rui (författare)
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Ren, Yifei (författare)
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- Liu, Cuicui (författare)
- Karolinska Institutet
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Zhu, Min (författare)
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Zhang, Heng (författare)
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- Wang, Yongxiang (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, P.R. China; Shandong Provincial Clinical Research Center for Neurological Diseases, P.R. China; Shandong First Medical University & Shandong Academy of Medical Sciences, P.R. China
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Cong, Lin (författare)
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Du, Yifeng (författare)
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- Qiu, Chengxuan (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, P.R. China
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: The American journal of geriatric psychiatry. - 1064-7481 .- 1545-7214. ; 32:2, s. 151-162
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: To investigate the associations of triglyceride-glucose (TyG) index, a reliable surrogate marker for insulin resistance, with the function of various cognitive domains and brain structures among older adults.Design: A population-based cross-sectional study.Setting: Older adults living in the rural communities in China.Participants: About 4,541 rural-dwelling dementia-free participants (age ≥65 years; 56.37% women) undertook examinations in March–September 2018 for MIND-China.Measurements: TyG index was calculated as ln[fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. A neuropsychological test battery was used to assess memory, attention, verbal fluency, and executive function. Volumetric brain measures were assessed on magnetic resonance imaging (MRI) in a subsample (n = 1,019). Data were analyzed with restricted cubic spline and multivariable general linear models.Results: An inverted J-shaped association was observed between TyG index and z-scores of multiple cognitive domains, such that among individuals with TyG index ≥8.57 (median), a higher TyG index was significantly associated with lower z-scores of memory, attention, verbal fluency, executive function, and global cognition (all p < 0.05); among people with TyG index <8.57, a higher TyG index was significantly associated with a higher executive function z-score (p < 0.05), but not with any of the other examined cognitive domains. In the MRI subsample, a higher TyG index was significantly associated with lower volumes of total brain tissue, gray matter, and white matter as well as greater cerebrospinal fluid volume (p < 0.05), but not with white matter hyperintensity volume.Conclusions: Insulin resistance, as indicated by a high TyG index, was associated with poor function in multiple cognitive domains and global brain atrophy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Cognitive function
- insulin resistance
- population-based study
- structural brain aging
- TyG index
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Tian, Na
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Song, Lin
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Hou, Tingting
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Fa, Wenxin
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Dong, Yi
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Liu, Rui
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visa fler...
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Ren, Yifei
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Liu, Cuicui
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Zhu, Min
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Zhang, Heng
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Wang, Yongxiang
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Cong, Lin
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Du, Yifeng
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Qiu, Chengxuan
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visa färre...
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Stockholms universitet
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Karolinska Institutet