WFRF:(Eliasson M)
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Induction of gut mucosal immune responses: importance of genetic background and Th1/Th2 cross-regulation.
- Kjerrulf, Martin (author)
-
- Grdic Eliasson, Dubravka (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institute of Medical Microbiology/Immunology
- Kopf, M (author)
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- (creator_code:org_t)
- 1998
- 1998
- English.
- In: Scandinavian journal of immunology. - 0300-9475. ; 47:5, s. 401-7
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The reciprocal regulation of T-helper cell (Th) subsets is widely documented in various animal models of infectious diseases. In this study IFN-gamma/IL-4 double knockout (DKO) mice were used to analyse the role of Th subsets in mucosal immune responses. We found that the DKO mice had normal IgA differentiation but impaired induction of specific gut mucosal antibody responses after oral immunization using cholera toxin adjuvant. Both Th1 and Th2 responses were reduced compared with wild-type mice. Despite the absence of both IFN-gamma and IL-4 in the DKO mice the overall results were similar to previous observations in IFN-gamma receptor-knockout (IFN-gammaR-/-) mice and did not suggest a strict cross-regulation of the two Th subsets in the gut mucosa. To further examine the role of IFN-gamma in mucosal immunity we compared two different mouse strains lacking IFN-gamma, i.e. IFN-gamma-/- (C57BL/6) and IFN-gammaR-/- mice (129/Sv). We found that IFN-gammaR-/- mice exhibited reduced mucosal antibody responses and decreased Th1 and Th2 activity after oral immunization, while IFN-gamma-/- mice had intact antibody responses and increased Th2 responses. Thus, genetic differences were found to critically affect the development of a specific gut mucosal immune response. An enhanced Th2 activity in the Peyer's patches following oral immunization was associated with an ability to mount strong intestinal IgA immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Animals
- Antibody Formation
- Female
- Immunity
- Mucosal
- genetics
- immunology
- Immunoglobulin A
- Secretory
- immunology
- Interferon-gamma
- genetics
- Interleukin-4
- genetics
- Intestinal Mucosa
- immunology
- Male
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- Peyer's Patches
- immunology
- Proteins
- immunology
- Receptors
- Interferon
- genetics
- Solubility
- Th1 Cells
- immunology
- Th2 Cells
- immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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