WFRF:(Huang XL)
Sökning: WFRF:(Huang XL) > PDGFD switches on s...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02619naa a2200481 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:150255804 | |
| 003 | SwePub | |
| 008 | 240811s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1502558042 URI |
| 024 | 7 | a https://doi.org/10.1007/s10456-022-09847-42 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lu, WS4 aut |
| 245 | 1 0 | a PDGFD switches on stem cell endothelial commitment |
| 264 | c 2022-07-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a The critical factors regulating stem cell endothelial commitment and renewal remain not well understood. Here, using loss- and gain-of-function assays together with bioinformatic analysis and multiple model systems, we show that PDGFD is an essential factor that switches on endothelial commitment of embryonic stem cells (ESCs). PDGFD genetic deletion or knockdown inhibits ESC differentiation into EC lineage and increases ESC self-renewal, and PDGFD overexpression activates ESC differentiation towards ECs. RNA sequencing reveals a critical requirement of PDGFD for the expression of vascular-differentiation related genes in ESCs. Importantly, PDGFD genetic deletion or knockdown increases ESC self-renewal and decreases blood vessel densities in both embryonic and neonatal mice and in teratomas. Mechanistically, we reveal that PDGFD fulfills this function via the MAPK/ERK pathway. Our findings provide new insight of PDGFD as a novel regulator of ESC fate determination, and suggest therapeutic implications of modulating PDGFD activity in stem cell therapy. | |
| 700 | 1 | a Xu, PP4 aut |
| 700 | 1 | a Deng, BX4 aut |
| 700 | 1 | a Zhang, JN4 aut |
| 700 | 1 | a Zhan, Y4 aut |
| 700 | 1 | a Lin, XC4 aut |
| 700 | 1 | a Xu, XZ4 aut |
| 700 | 1 | a Xia, ZX4 aut |
| 700 | 1 | a Yang, XX4 aut |
| 700 | 1 | a Zeng, XL4 aut |
| 700 | 1 | a Huang, LJ4 aut |
| 700 | 1 | a Xie, BB4 aut |
| 700 | 1 | a Wang, CH4 aut |
| 700 | 1 | a Wang, SS4 aut |
| 700 | 1 | a Kuang, HQ4 aut |
| 700 | 1 | a Han, XJ4 aut |
| 700 | 1 | a Mora, A4 aut |
| 700 | 1 | a Cao, YHu Karolinska Institutet4 aut |
| 700 | 1 | a Jiang, Q4 aut |
| 700 | 1 | a Li, XR4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Angiogenesisd : Springer Science and Business Media LLCg 25:4, s. 517-533q 25:4<517-533x 1573-7209x 0969-6970 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:150255804 |
| 856 | 4 8 | u https://doi.org/10.1007/s10456-022-09847-4 |
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