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FältnamnIndikatorerMetadata
00012304naa a2200949 4500
001oai:DiVA.org:uu-443195
003SwePub
008210528s2021 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:9097e5ff-635e-4a49-ba63-c7ee9f1bf16e
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4431952 URI
0247 a https://doi.org/10.1038/s41467-021-22465-w2 DOI
0247 a https://lup.lub.lu.se/record/9097e5ff-635e-4a49-ba63-c7ee9f1bf16e2 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Viborg Lindskrog, Siau Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
2451 0a An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
264 c 2021-04-16
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
520 a The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
7001 a Prip, Frederiku Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Lamy, Philippeu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital4 aut
7001 a Taber, Annu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Groeneveld, Clarice S.u Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France; Inst Curie, UMR144, Oncol Mol, Paris, France,Curie Institute, Paris,Ligue Nationale Contre le Cancer4 aut
7001 a Birkenkamp-Demtröder, Karinu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Bjerggaard Jensen, Jørgenu Aarhus Univ, Dept Clin Med, Aarhus, Denmark; Aarhus Univ Hosp, Dept Urol, Aarhus N, Denmark,Aarhus University Hospital4 aut
7001 a Strandgaard, Trineu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Nordentoft, Iveru Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital4 aut
7001 a Christensen, Emilu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Sokac, Mateou Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Birkbak, Nicolai J.u Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Maretty, Lasseu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7001 a Hermann, Gregers G.u Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen4 aut
7001 a Petersen, Astrid C.u Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark,Aalborg University Hospital4 aut
7001 a Weyerer, Veronikau Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen4 aut
7001 a Grimm, Marc-Oliveru Jena Univ Hosp, Dept Urol, Jena, Germany,Universitätsklinikum Jena4 aut
7001 a Horstmann, Marcusu Jena Univ Hosp, Dept Urol, Jena, Germany; St Josephshosp, Dept Urol, Malteser Hosp, Krefeld, Germany,St. Josefs Hospital Uerdingen,Universitätsklinikum Jena4 aut
7001 a Sjödahl, Gottfridu Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Genomiska analyser av urinblåscancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,Urothelial Cancer Genomics,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Urol Res, Malmö, Sweden4 aut0 (Swepub:lu)med-gsj
7001 a Höglund, Mattiasu Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden4 aut0 (Swepub:lu)kgen-mho
7001 a Steiniche, Torbenu Aarhus Univ Hosp, Dept Pathol, Aarhus N, Denmark,Aarhus University Hospital4 aut
7001 a Mogensen, Karinu Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen4 aut
7001 a de Reyniès, Aurélienu Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France,Ligue Nationale Contre le Cancer4 aut
7001 a Nawroth, Romanu Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany4 aut
7001 a Jordan, Brianu Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut
7001 a Lin, Xiaoqiu Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut
7001 a Dragicevic, Dejanu Univ Belgrade, Fac Med, Clin Ctr Serbia, Clin Urol, Belgrade, Serbia,University of Belgrade,Leeds School of Medicine,Pennsylvania State University,Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA4 aut
7001 a Ward, Douglas G.u Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut
7001 a Goel, Anshitau Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut
7001 a Hurst, Carolyn D.u Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England4 aut
7001 a Raman, Jay D.u Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA4 aut
7001 a Warrick, Joshua I.u Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University4 aut
7001 a Segersten, Ulrikau Uppsala University,Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)ulriande
7001 a Sikic, Danijelu Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Urol & Pediat Urol, Erlangen, Germany,University Hospital Erlangen4 aut
7001 a van Kessel, Kim E. M.u Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center4 aut
7001 a Maurer, Tobiasu Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany; Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany,University Medical Center Hamburg-Eppendorf4 aut
7001 a Meeks, Joshua J.u Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut
7001 a DeGraff, David J.u Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University4 aut
7001 a Bryan, Richard T.u Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut
7001 a Knowles, Margaret A.u Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Leeds School of Medicine4 aut
7001 a Simic, Tatjanau Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia,University of Belgrade4 aut
7001 a Hartmann, Arndtu Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen4 aut
7001 a Zwarthoff, Ellen C.u Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center4 aut
7001 a Malmström, Per-Unou Uppsala University,Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)perunoms
7001 a Malats, Núriau CIBERONC, Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain,Spanish National Cancer Research Center (CNIO)4 aut
7001 a Real, Francisco X.u Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain; Univ Pompeu Fabra, Dept Ciencies Expt & Salut, CIBERONC, Barcelona, Spain,Pompeu Fabra University,Spanish National Cancer Research Center (CNIO)4 aut
7001 a Dyrskjøt, Larsu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut
7102 a Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmarkb Aarhus University Hospital4 org
7730 t Nature Communicationsd : Springer Natureg 12:1q 12:1x 2041-1723
8564 u https://doi.org/10.1038/s41467-021-22465-wy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1558085/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41467-021-22465-w.pdf
8564 u http://dx.doi.org/10.1038/s41467-021-22465-wx freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443195
8564 8u https://doi.org/10.1038/s41467-021-22465-w
8564 8u https://lup.lub.lu.se/record/9097e5ff-635e-4a49-ba63-c7ee9f1bf16e

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