Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project

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Fältnamn	Indikatorer	Metadata
000		07383naa a2201285 4500
001		oai:DiVA.org:su-102469
003		SwePub
008		140407s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-84234
009		oai:prod.swepub.kib.ki.se:128440711
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1024692 URI
024	7	a https://doi.org/10.1016/S0140-6736(13)62158-32 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-842342 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1284407112 URI
040		a (SwePub)sud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Beelen, Rob4 aut
245	1 0	a Effects of long-term exposure to air pollution on natural-cause mortality :b an analysis of 22 European cohorts within the multicentre ESCAPE project
264	1	b Elsevier,c 2014
338		a print2 rdacarrier
500		a AuthorCount:76;
520		a Background Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants. Methods We used data from 22 European cohort studies, which created a total study population of 367 251 participants. All cohorts were general population samples, although some were restricted to one sex only. With a strictly standardised protocol, we assessed residential exposure to air pollutants as annual average concentrations of particulate matter (PM) with diameters of less than 2.5 mu m (PM2.5), less than 10 mu m (PM10), and between 10 mu m and 2.5 mu m (PMcoarse), PM2.5 absorbance, and annual average concentrations of nitrogen oxides (NO2 and NOx), with land use regression models. We also investigated two traffic intensity variables-traffic intensity on the nearest road (vehicles per day) and total traffic load on all major roads within a 100 m buff er. We did cohort-specific statistical analyses using confounder models with increasing adjustment for confounder variables, and Cox proportional hazards models with a common protocol. We obtained pooled effect estimates through a random-effects meta-analysis. Findings The total study population consisted of 367 251 participants who contributed 5 118 039 person-years at risk (average follow-up 13.9 years), of whom 29 076 died from a natural cause during follow-up. A significantly increased hazard ratio (HR) for PM2.5 of 1.07 (95% CI 1.02-1.13) per 5 mu g/m(3) was recorded. No heterogeneity was noted between individual cohort effect estimates (I-2 p value=0.95). HRs for PM2.5 remained significantly raised even when we included only participants exposed to pollutant concentrations lower than the European annual mean limit value of 25 mu g/m(3) (HR 1.06, 95% CI 1.00-1.12) or below 20 mu g/m(3) (1.07, 1.01-1.13). Interpretation Long-term exposure to fine particulate air pollution was associated with natural-cause mortality, even within concentration ranges well below the present European annual mean limit value.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskap0 (SwePub)3032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciences0 (SwePub)3032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
700	1	a Raaschou-Nielsen, Ole4 aut
700	1	a Stafoggia, Massimo4 aut
700	1	a Andersen, Zorana Jovanovic4 aut
700	1	a Weinmayr, Gudrun4 aut
700	1	a Hoffmann, Barbara4 aut
700	1	a Wolf, Kathrin4 aut
700	1	a Samoli, Evangelia4 aut
700	1	a Fischer, Paul4 aut
700	1	a Nieuwenhuijsen, Mark4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Xun, Wei W.4 aut
700	1	a Katsouyanni, Klea4 aut
700	1	a Dimakopoulou, Konstantina4 aut
700	1	a Oudin, Annau Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)anou0004
700	1	a Forsberg, Bertilu Umeå universitet,Yrkes- och miljömedicin,Arcum4 aut0 (Swepub:umu)befo0001
700	1	a Modig, Larsu Umeå universitet,Yrkes- och miljömedicin4 aut0 (Swepub:umu)lasmog96
700	1	a Havulinna, Aki S.4 aut
700	1	a Lanki, Timo4 aut
700	1	a Turunen, Anu4 aut
700	1	a Oftedal, Bente4 aut
700	1	a Nystad, Wenche4 aut
700	1	a Nafstad, Per4 aut
700	1	a De Faire, Ulfu Karolinska Institutet4 aut
700	1	a Pedersen, Nancy L.u Karolinska Institutet4 aut
700	1	a Östenson, Claes-Göranu Karolinska Institutet4 aut
700	1	a Fratiglioni, Laurau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut
700	1	a Penell, Johanna4 aut
700	1	a Korek, Michalu Karolinska Institutet4 aut
700	1	a Pershagen, Göranu Karolinska Institutet4 aut
700	1	a Eriksen, Kirsten Thorup4 aut
700	1	a Overvad, Kim4 aut
700	1	a Ellermann, Thomas4 aut
700	1	a Eeftens, Marloes4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a Meliefste, Kees4 aut
700	1	a Wang, Meng4 aut
700	1	a Bueno-de-Mesquita, Bas4 aut
700	1	a Sugiri, Dorothea4 aut
700	1	a Kraemer, Ursula4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a de Hoogh, Kees4 aut
700	1	a Key, Timothy4 aut
700	1	a Peters, Annette4 aut
700	1	a Hampel, Regina4 aut
700	1	a Concin, Hans4 aut
700	1	a Nagel, Gabriele4 aut
700	1	a Ineichen, Alex4 aut
700	1	a Schaffner, Emmanuel4 aut
700	1	a Probst-Hensch, Nicole4 aut
700	1	a Kuenzli, Nino4 aut
700	1	a Schindler, Christian4 aut
700	1	a Schikowski, Tamara4 aut
700	1	a Adam, Martin4 aut
700	1	a Phuleria, Harish4 aut
700	1	a Vilier, Alice4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Declercq, Christophe4 aut
700	1	a Grioni, Sara4 aut
700	1	a Krogh, Vittorio4 aut
700	1	a Tsai, Ming-Yi4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Galassi, Claudia4 aut
700	1	a Migliore, Enrica4 aut
700	1	a Ranzi, Andrea4 aut
700	1	a Cesaroni, Giulia4 aut
700	1	a Badaloni, Chiara4 aut
700	1	a Forastiere, Francesco4 aut
700	1	a Tamayo, Ibon4 aut
700	1	a Amiano, Pilar4 aut
700	1	a Dorronsoro, Miren4 aut
700	1	a Katsoulis, Michail4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Brunekreef, Bert4 aut
700	1	a Hoek, Gerard4 aut
710	2	a Umeå universitetb Yrkes- och miljömedicin4 org
773	0	t The Lancetd : Elsevierg 383:9919, s. 785-795q 383:9919<785-795x 0140-6736x 1474-547X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102469
856	4 8	u https://doi.org/10.1016/S0140-6736(13)62158-3
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84234
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:128440711

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Av författaren/redakt...: Beelen, Rob; Raaschou-Nielsen ...; Stafoggia, Massi ...; Andersen, Zorana ...; Weinmayr, Gudrun; Hoffmann, Barbar ...; visa fler...; Wolf, Kathrin; Samoli, Evangeli ...; Fischer, Paul; Nieuwenhuijsen, ...; Vineis, Paolo; Xun, Wei W.; Katsouyanni, Kle ...; Dimakopoulou, Ko ...; Oudin, Anna; Forsberg, Bertil; Modig, Lars; Havulinna, Aki S ...; Lanki, Timo; Turunen, Anu; Oftedal, Bente; Nystad, Wenche; Nafstad, Per; De Faire, Ulf; Pedersen, Nancy ...; Östenson, Claes- ...; Fratiglioni, Lau ...; Penell, Johanna; Korek, Michal; Pershagen, Göran; Eriksen, Kirsten ...; Overvad, Kim; Ellermann, Thoma ...; Eeftens, Marloes; Peeters, Petra H ...; Meliefste, Kees; Wang, Meng; Bueno-de-Mesquit ...; Sugiri, Dorothea; Kraemer, Ursula; Heinrich, Joachi ...; de Hoogh, Kees; Key, Timothy; Peters, Annette; Hampel, Regina; Concin, Hans; Nagel, Gabriele; Ineichen, Alex; Schaffner, Emman ...; Probst-Hensch, N ...; Kuenzli, Nino; Schindler, Chris ...; Schikowski, Tama ...; Adam, Martin; Phuleria, Harish; Vilier, Alice; Clavel-Chapelon, ...; Declercq, Christ ...; Grioni, Sara; Krogh, Vittorio; Tsai, Ming-Yi; Ricceri, Fulvio; Sacerdote, Carlo ...; Galassi, Claudia; Migliore, Enrica; Ranzi, Andrea; Cesaroni, Giulia; Badaloni, Chiara; Forastiere, Fran ...; Tamayo, Ibon; Amiano, Pilar; Dorronsoro, Mire ...; Katsoulis, Micha ...; Trichopoulou, An ...; Brunekreef, Bert; Hoek, Gerard; visa färre...

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