A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren

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Fältnamn	Indikatorer	Metadata
000		05751naa a2200733 4500
001		oai:gup.ub.gu.se/224029
003		SwePub
008		240528s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-264667
009		oai:DiVA.org:umu-109914
024	7	a https://gup.ub.gu.se/publication/2240292 URI
024	7	a https://doi.org/10.1111/pai.124222 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2646672 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1099142 URI
040		a (SwePub)gud (SwePub)uud (SwePub)umu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Bjerg, Anders,d 1982u Umeå universitet,Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Krefting Res Ctr, Dept Internal Med & Clin Nutr, SE-40530 Gothenburg, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, OLIN Unit, Occupat & Environm,Med, Umea, Sweden.,Yrkes- och miljömedicin,Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Göteborg, Sweden4 aut0 (Swepub:umu)ansbjd01
245	1 0	a A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
264		c 2015-07-30
264	1	b Wiley,c 2015
520		a BackgroundAnimal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren. MethodsA random sample of 696 children (11-12years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire. ResultsOf 259 animal-sensitized children (0.1 kU(A)/l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma. ConclusionsAmong schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653		a children
653		a allergy
653		a furry animals
653		a allergen components
653		a component-resolved diagnosis
653		a asthma
653		a rhinitis
653		a obstructive lung-disease
653		a severe childhood asthma
653		a northern sweden
653		a allergic sensitization
653		a ige sensitization
653		a risk-factors
653		a time trends
653		a children
653		a food
653		a cat
653		a Allergy
653		a Immunology
653		a Pediatrics
653		a children
700	1	a Winberg, Annau Umeå universitet,Pediatrik4 aut0 (Swepub:umu)anwi0077
700	1	a Berthold, M.u ThermoFisher Sci, Uppsala, Sweden.4 aut
700	1	a Mattsson, L.u ThermoFisher Sci, Uppsala, Sweden.4 aut
700	1	a Borres, Magnus P.u Uppsala universitet,Pediatrik,ThermoFisher Sci, Uppsala, Sweden.4 aut0 (Swepub:uu)magbo385
700	1	a Rönmark, Eva,d 1953u Umeå universitet,Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Krefting Res Ctr, Dept Internal Med & Clin Nutr, SE-40530 Gothenburg, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, OLIN Unit, Occupat & Environm,Med, Umea, Sweden.,Yrkes- och miljömedicin,Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Göteborg, Sweden4 aut0 (Swepub:umu)evra0004
710	2	a Göteborgs universitetb Krefting Research Centre4 org
773	0	t Pediatric Allergy and Immunologyd : Wileyg 26:6, s. 557-563q 26:6<557-563x 0905-6157x 1399-3038
856	4 8	u https://gup.ub.gu.se/publication/224029
856	4 8	u https://doi.org/10.1111/pai.12422
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-264667
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109914

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Av författaren/redakt...: Bjerg, Anders, 1 ...; Winberg, Anna; Berthold, M.; Mattsson, L.; Borres, Magnus P ...; Rönmark, Eva, 19 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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