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Sökning: WFRF:(Paez M. A.) > Change of tumour ch...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003935naa a2200385 4500
001oai:gup.ub.gu.se/130928
003SwePub
008240528s2010 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/1309282 URI
0247 a https://doi.org/10.1016/j.ejca.2010.09.0332 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Boevee, S J4 aut
2451 0a Change of tumour characteristics and treatment over time in both arms of the European Randomized study of Screening for Prostate Cancer.
264 1b Elsevier BV,c 2010
520 a Objective To evaluate a change in tumour characteristics and applied treatments over time in the control arm of all centres of the European Randomized study of Screening for Prostate Cancer (ERSPC) and to compare this with similar data of the screening arm. Methods Between 1993 and 2003, 182,160 men, aged 50–74 years, were randomised to the screening arm (N = 82,816) and the control arm (N = 99,184). Men in the screening arm were offered Prostate Specific Antigen (PSA) testing every 4 years whilst men in the control arm received usual care. Tumour characteristics and treatment were evaluated in all men diagnosed with prostate cancer up to December 2006 or the third screening round. Data on the control arm were divided into 3 periods: 1994–1998, 1999–2002 and 2003–2006. Results Tumour characteristics were more favourable over time in both the control and the screening arm, with especially increasing proportions of T1C tumours with 29% in 1994–1998 versus 50% in 2003–2006 and 48% at the initial screening round versus 75% at the third screening round, respectively. Tumour characteristics observed in the last period of the control arm were comparable to tumour characteristics in the initial screening round. In the control arm, treatment changed over time with surgery as the most common treatment in the entire observed period, but almost doubling of expectant management and the combination of hormone therapy and radiotherapy over time. In the initial screening round, surgery was the most common treatment (42%), changing over time to expectant management as the most frequently applied treatment in the third screening round (33%). Conclusion Tumour characteristics in the control arm became more favourable over time and show similarity with prostate cancer cases detected at the initial screening round. The most prominent change in treatment over time was an increase of application of expectant management in both arms of the ERSPC. These observations reflect an increasing rate of opportunistic testing over time in men randomised to the control arm.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a Prostate cancer; Prognostic factors; Screening; Screen versus control arm; Treatment; Stage; Grade; Randomised trial
7001 a Venderbos, L D F4 aut
7001 a Tammela, T L J4 aut
7001 a Nelen, V4 aut
7001 a Ciatto, S4 aut
7001 a Kwiatkowski, M4 aut
7001 a Páez, A4 aut
7001 a Malavaud, B4 aut
7001 a Hugosson, Jonas,d 1955u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology4 aut0 (Swepub:gu)xhugjo
7001 a Roobol, M J4 aut
7102 a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för urologi4 org
7730 t European journal of cancerd : Elsevier BVg 46:17, s. 3082-3089q 46:17<3082-3089x 1879-0852x 0959-8049
8564 8u https://gup.ub.gu.se/publication/130928
8564 8u https://doi.org/10.1016/j.ejca.2010.09.033

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