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  • Nilsson, Magnus (author)

Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof : A potent inhibitor of Hepatitis C virus replication

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • Elsevier BV,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-212500
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212500URI
  • https://doi.org/10.1016/j.bmcl.2012.03.021DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • 928EN Times Cited:1 Cited References Count:21
  • 4'-Azido-2'-deoxy-2'-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 mu M and showing moderate in vivo bioavailability in rat (F = 14%). Here we describe the synthesis and biological evaluation of 4'-azido-2'-deoxy-2'-methylcytidine and prodrug derivatives thereof. (C) 2012 Elsevier Ltd. All rights reserved.

Subject headings and genre

  • NATURVETENSKAP Kemi hsv//swe
  • NATURAL SCIENCES Chemical Sciences hsv//eng
  • hepatitis c virus
  • ns5b polymerase
  • antivirals
  • nucleoside
  • prodrug
  • phosphoramidate
  • genotype 1 infection
  • antiviral activity
  • viral-hepatitis
  • analogs
  • design
  • 4'-azidocytidine
  • boceprevir
  • telaprevir
  • resistance

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kalayanov, Genadiy (author)
  • Winqvist, Anna (author)
  • Pinho, Pedro (author)
  • Sund, Christian (author)
  • Zhou, Xiao- Xiong (author)
  • Wahling, Horst (author)
  • Belfrage, Anna Karin,1977-Medivir AB, PO Box 1086, SE-141 22 Huddinge, Sweden(Swepub:uu)annbe939 (author)
  • Pelcman, Michael (author)
  • Agback, Tatiana (author)
  • Benckestock, Kurt (author)
  • Wikström, Kristina (author)
  • Boothee, Mirva (author)
  • Lindqvist, Anneli (author)
  • Rydegard, Christina (author)
  • Jonckers, Tim H. M. (author)
  • Vandyck, Koen (author)
  • Raboisson, Pierre (author)
  • Lin, Tse-I (author)
  • Lachau-Durand, Sophie (author)
  • de Kock, Herman (author)
  • Smith, David B. (author)
  • Martin, Joseph A. (author)
  • Klumpp, Klaus (author)
  • Simmen, Kenneth (author)
  • Vrang, Lotta (author)
  • Terelius, Ylva (author)
  • Samuelsson, Bertil (author)
  • Rosenquist, Åsa (author)
  • Johansson, Nils Gunnar (author)
  • Medivir AB, PO Box 1086, SE-141 22 Huddinge, Sweden (creator_code:org_t)

Related titles

  • In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV22:9, s. 3265-32680960-894X1464-3405

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