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WFRF:(Santos Antonio M)
 

Sökning: WFRF:(Santos Antonio M) > (2020-2023) > Cellular Aging Secr...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004968naa a2200613 4500
001oai:lup.lub.lu.se:a3ef1b9c-1637-496c-afec-141da5c51bfe
003SwePub
008221219s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:150802870
0247 a https://lup.lub.lu.se/record/a3ef1b9c-1637-496c-afec-141da5c51bfe2 URI
0247 a https://doi.org/10.1007/s12015-022-10453-62 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1508028702 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Marote, Anau University of Minho4 aut0 (Swepub:lu)an4132ma
2451 0a Cellular Aging Secretes : a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture
264 c 2022-09-24
264 1b Springer Science and Business Media LLC,c 2023
520 a Mesenchymal stem cells (MSCs) hold promising therapeutic potential in several clinical applications, mainly due to their paracrine activity. The implementation of future secretome-based therapeutic strategies requires the use of easily accessible MSCs sources that provide high numbers of cells with homogenous characteristics. MSCs obtained from induced pluripotent stem cells (iMSCs) have been put forward as an advantageous alternative to the gold-standard tissue sources, such as bone marrow (BM-MSCs). In this study, we aimed at comparing the secretome of BM-MSCs and iMSCs over long-term culture. For that, we performed a broad characterization of both sources regarding their identity, proteomic secretome analysis, as well as replicative senescence and associated phenotypes, including its effects on MSCs secretome composition and immunomodulatory action. Our results evidence a rejuvenated phenotype of iMSCs, which is translated into a superior proliferative capacity before the induction of replicative senescence. Despite this significant difference between iMSCs and BM-MSCs proliferation, both untargeted and targeted proteomic analysis revealed a similar secretome composition for both sources in pre-senescent and senescent states. These results suggest that shifting from the use of BM-MSCs to a more advantageous source, like iMSCs, may yield similar therapeutic effects as identified over the past years for this gold-standard MSC source. Graphical Abstract: [Figure not available: see fulltext.].
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653 a Bone marrow
653 a Human platelet lysate
653 a Induced pluripotent stem cells
653 a Mesenchymal stem cells
653 a Replicative senescence
653 a Secretome
653 a Senescence-associated secretory profile
7001 a Santos, Diogou University of Minho4 aut
7001 a Mendes-Pinheiro, Bárbarau University of Minho4 aut
7001 a Serre-Miranda, Cláudiau University of Minho4 aut
7001 a Anjo, Sandra I.u University of Coimbra4 aut
7001 a Vieira, Joanau Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Ferreira-Antunes, Filipau University of Minho4 aut
7001 a Correia, Joana Sofiau University of Minho4 aut
7001 a Borges-Pereira, Carolineu University of Minho4 aut
7001 a Pinho, Andreia G.u University of Minho4 aut
7001 a Campos, Jonasu University of Minho4 aut
7001 a Manadas, Brunou University of Coimbra4 aut
7001 a Teixeira, Manuel R.u University of Porto,Instituto Português de Oncologia do Porto Francisco Gentil (IPO)4 aut
7001 a Correia-Neves, Margaridau Karolinska Institutet4 aut
7001 a Pinto, Luísau University of Minho4 aut
7001 a Costa, Pedro M.4 aut
7001 a Roybon, Laurentu Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund4 aut0 (Swepub:lu)mphy-lra
7001 a Salgado, António J.u University of Minho4 aut
7102 a University of Minhob University of Coimbra4 org
7730 t Stem Cell Reviews and Reportsd : Springer Science and Business Media LLCg 19:1, s. 248-263q 19:1<248-263x 2629-3269x 2629-3277
8564 u http://dx.doi.org/10.1007/s12015-022-10453-6y FULLTEXT
8564 8u https://lup.lub.lu.se/record/a3ef1b9c-1637-496c-afec-141da5c51bfe
8564 8u https://doi.org/10.1007/s12015-022-10453-6
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:150802870

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