Sökning: WFRF:(Smedby K) > Rheumatoid Arthriti...
Fältnamn | Indikatorer | Metadata |
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000 | 03990naa a2200445 4500 | |
001 | oai:DiVA.org:uu-318580 | |
003 | SwePub | |
008 | 170326s2017 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:135388158 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3185802 URI |
024 | 7 | a https://doi.org/10.1002/art.400172 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1353881582 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hellgren, K.u Karolinska Institutet4 aut |
245 | 1 0 | a Rheumatoid Arthritis and Risk of Malignant Lymphoma - Is the risk still increased? |
264 | c 2017-03-29 | |
264 | 1 | b Wiley,c 2017 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVE: Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas with a strong correlation with RA disease severity. Given the changes in RA therapy over recent decades, we aimed at assessing whether lymphoma risk remains increased, and if so, to explore risk predictors and lymphoma subtypes.METHODS: We identified 12,656 incident RA patients from the Swedish Rheumatology Register 1997-2012 including information on therapy and inflammatory activity during the first year following diagnosis. Each patient was matched to 10 population comparator subjects. Through linkage to the Swedish Cancer Register, lymphomas including subtypes were identified. We assessed Hazard ratios (HRs) using Cox regression.RESULTS: Overall, the HR of lymphoma was increased, 1.6, 95% confidence interval [CI] 1.2-2.1. Taking RA duration into account, risks did not appear to have declined over successive calendar years of RA diagnosis. Neither use of methotrexate the 1(st) year following RA diagnosis nor ever use of TNF inhibitors (HR=0.9; 95% CI 0.4-1.9) increased lymphoma risk. Use of oral corticosteroids the 1(st) year following RA diagnosis was associated with a reduced risk (HR=0.6; 95% CI 0.5 -0.9). Inflammatory activity during the 1(st) year following RA diagnosis did not predict future lymphoma risk. Chronic lymphocytic lymphoma occurred less, and Hodgkin lymphoma more frequently than expected compared to the general population.CONCLUSION: The average lymphoma risk in recently diagnosed RA is of similar magnitude as that reported from historical cohorts. Standard anti-rheumatic treatment including TNF inhibitors did not predict future lymphoma risk. Distribution of lymphoma subtypes warrants further investigation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Baecklund, Eva,d 1956-u Uppsala universitet,Reumatologi4 aut0 (Swepub:uu)evaba786 |
700 | 1 | a Backlin, Carinu Uppsala universitet,Reumatologi4 aut0 (Swepub:uu)kariback |
700 | 1 | a Sundström, Christeru Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini4 aut0 (Swepub:uu)chrisund |
700 | 1 | a Smedby, K. E.u Karolinska Institutet4 aut |
700 | 1 | a Askling, J.u Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Reumatologi4 org |
773 | 0 | t Arthritis & Rheumatologyd : Wileyg 69:4, s. 700-708q 69:4<700-708x 2326-5191x 2326-5205 |
856 | 4 | u https://www.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.40017 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-318580 |
856 | 4 8 | u https://doi.org/10.1002/art.40017 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135388158 |
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