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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003367naa a2200409 4500
001oai:DiVA.org:uu-184949
003SwePub
008121115s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1849492 URI
0247 a https://doi.org/10.1016/j.metabol.2012.04.0032 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Jans, A.4 aut
2451 0a Impact of dietary fat quantity and quality on skeletal muscle fatty acid metabolism in subjects with the metabolic syndrome
264 1b Elsevier BV,c 2012
338 a print2 rdacarrier
520 a Insulin resistance is characterized by disturbances in lipid metabolism in skeletal muscle. Our aim was to investigate whether gene expression and fatty acid (FA) profile of skeletal muscle lipids are affected by diets differing in fat quantity and quality in subjects with the metabolic syndrome (MetS) and varying degrees of insulin sensitivity. 84 subjects (age 57.3 ± 0.9 y, BMI 30.9 ± 0.4 kg/m 2, 42 M/42 F) were randomly assigned to one of four iso-energetic diets: high-SFA (HSFA); high-MUFA (HMUFA) or two low-fat, high-complex carbohydrate diets, supplemented with 1.24 g/day of long-chain n-3 PUFA (LFHCCn-3) or control oil (LFHCC) for 12 weeks. In a subgroup of men (n = 26), muscle TAG, DAG, FFA and phospholipid contents were determined including their fractional synthetic rate (FSR) and FA composition at fasting and 4 h after consumption of a high-fat mixed-meal, both pre- and post-intervention. Genes involved in lipogenesis were downregulated after HMUFA (mean fold change - 1.3) and after LFHCCn-3 (fold change - 1.7) in insulin resistant subjects (< median of (S I)), whereas in insulin sensitive subjects (> median of insulin sensitivity) the opposite effect was shown (fold change + 1.6 for both diets). HMUFA diet tended to decrease FSR in TAG (P =.055) and DAG (P =.066), whereas the LFHCCn-3 diet reduced TAG content (P =.032). In conclusion, HMUFA and LFHCCn-3 diets reduced the expression of the lipogenic genes in skeletal muscle of insulin resistant subjects, whilst HMUFA reduced the fractional synthesis rate of DAG and TAG and LFHCC n-3 the TAG content. Our data indicate that these diets may reduce muscle fat accumulation by affecting the balance between FA synthesis, storage and oxidation.
653 a Gene expression
653 a Insulin resistance
653 a Skeletal muscle lipid fractions
7001 a Van Hees, A. M. J.4 aut
7001 a Gjelstad, I. M. F.4 aut
7001 a Sparks, L. M.4 aut
7001 a Tierney, A. C.4 aut
7001 a Risérus, Ulfu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
7001 a Drevon, C. A.4 aut
7001 a Schrauwen, P.4 aut
7001 a Roche, H. M.4 aut
7001 a Blaak, E. E.4 aut
7102 a Uppsala universitetb Klinisk nutrition och metabolism4 org
7730 t Metabolismd : Elsevier BVg 61:11, s. 1554-1565q 61:11<1554-1565x 0026-0495x 1532-8600
8564 u https://cris.maastrichtuniversity.nl/ws/files/75296992/Schrauwen_2012_Impact_of_dietary_fat_quantity.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-184949
8564 8u https://doi.org/10.1016/j.metabol.2012.04.003

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