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Sökning: WFRF:(Yang Xi) > (2020-2024) > Indoor microbiome, ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008595naa a2200601 4500
001oai:DiVA.org:uu-470579
003SwePub
008220328s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4705792 URI
0247 a https://doi.org/10.1016/j.envint.2022.1071372 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Sun, Yuu Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
2451 0a Indoor microbiome, air pollutants and asthma, rhinitis and eczema in preschool children - A repeated cross-sectional study
264 1b Elsevier,c 2022
338 a electronic2 rdacarrier
520 a Background: Indoor microbiome exposure is associated with asthma, rhinitis and eczema. However, no studies report the interactions between environmental characteristics, indoor microbiome and health effects in a repeated cross-sectional framework. Methods: 1,279 and 1,121 preschool children in an industrial city (Taiyuan) of China were assessed for asthma, rhinitis and eczema symptoms in 2012 and 2019 by self-administered questionnaires, respectively. Bacteria and fungi in classroom vacuum dust were characterized by culture-independent amplicon sequencing. Multi-level logistic/linear regression was performed in two cross-sectional and two combined models to assess the associations. Results: The number of observed species in bacterial and fungal communities in classrooms increased significantly from 2012 to 2019, and the compositions of the microbial communities were drastically changed (p < 0.001). The temporal microbiome variation was significantly larger than the spatial variation within the city (p < 0.001). Annual average outdoor SO2 concentration decreased by 60.7%, whereas NO2 and PM10 concentra-tions increased by 63.3% and 40.0% from 2012 to 2019, which were both associated with indoor microbiome variation (PERMANOVA p < 0.001). The prevalence of asthma (2.0% to 3.3%, p = 0.06) and rhinitis (28.0% to 25.3%, p = 0.13) were not significantly changed, but the prevalence of eczema was increased (3.6% to 7.0%; p < 0.001). Aspergillus subversicolor, Collinsella and Cutibacterium were positively associated with asthma, rhinitis and eczema, respectively (p < 0.01). Prevotella, Lactobacillus iners and Dolosigranulum were protectively (negatively) associated with rhinitis (p < 0.01), consistent with previous studies in the human respiratory tract. NO2 and PM10 concentrations were negatively associated with rhinitis in a bivariate model, but a multivariate mediation analysis revealed that Prevotella fully mediated the health effects. Conclusions: This is the first study to report the interactions between environmental characteristics, indoor microbiome and health in a repeated cross-sectional framework. The mediating effects of indoor microorganisms suggest incorporating biological with chemical exposure for a comprehensive exposure assessment.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Amplicon sequencing
653 a Repeated cross-sectional study
653 a Microbial diversity and community variation
653 a Asthma
653 a Rhinitis
653 a Eczema
653 a Preschool children
653 a Air pollutants
7001 a Meng, Yiu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Ou, Zheyuanu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Li, Yanlingu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Zhang, Meiu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Chen, Yangu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Zhang, Zefeiu Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.4 aut
7001 a Chen, Xingyiu Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.4 aut
7001 a Mu, Peiqiangu South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 aut
7001 a Norbäck, Danu Uppsala universitet,Arbets- och miljömedicin4 aut0 (Swepub:uu)dagnorba
7001 a Zhao, Zhuohuiu Fudan Univ, Dept Environm Hlth, Sch Publ Hlth,Shanghai Typhoon Inst CMA,Shanghai, Key Lab Publ Hlth Safety,Minist Educ,NHC Key Lab, Shanghai 200030, Peoples R China.4 aut
7001 a Zhang, Xinu Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.4 aut
7001 a Fu, Xiu Guangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Peoples R China.;Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & As, Guangzhou, Peoples R China.4 aut
7102 a Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.b South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.4 org
7730 t Environment Internationald : Elsevierg 161q 161x 0160-4120x 1873-6750
8564 u https://doi.org/10.1016/j.envint.2022.107137y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1647462/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.envint.2022.107137
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470579
8564 8u https://doi.org/10.1016/j.envint.2022.107137

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