Promoter anchored interaction landscape of THP-1 macrophages captures early immune response processes

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Pradhananga, Sailendra (författare): KTH,Genteknologi,Science for Life Laboratory, SciLifeLab

Spalinskas, Rapolas, Dr. 1983- (författare): KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH)

Sahlén, Pelin (författare): KTH,Science for Life Laboratory, SciLifeLab,Genteknologi

(creator_code:org_t)

Elsevier BV, 2020
2020
Engelska.
Ingår i: Cellular Immunology. - : Elsevier BV. - 0008-8749 .- 1090-2163. ; 355

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Abstract Ämnesord

Stäng

Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulated THP-1 macrophages (0 and 2 h) using capture Hi-C. Success of LPS stimulation was validated with transcriptome sequencing. Circa 2900 genes changed their interaction profile upon LPS stimulation and those gaining interactions were enriched for LPS response relevant processes, suggesting a substantial role for distal regulation. Immune and cardiovascular risk variants were enriched within the interacting regions, thereby providing insights into macrophage biology.

Av författaren/redakt...: Pradhananga, Sai ...; Spalinskas, Rapo ...; Poujade, Flore-A ...; Eriksson, Per; Sahlén, Pelin

Om ämnet

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