Sökning: L773:1474 9726 >
Sex‐specific growth...
-
Lind, Martin I.,Dr,1980-Högskolan i Halmstad,Akademin för företagande, innovation och hållbarhet,Uppsala University, Uppsala, Sweden
(författare)
Sex‐specific growth and lifespan effects of germline removal in the dioecious nematode Caenorhabditis remanei
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
-
2024
-
Chichester :Wiley-Blackwell,2024
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:hh-54404
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-54404URI
-
https://doi.org/10.1111/acel.14290DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Germline regulates the expression of life-history traits and mediates the trade-off between reproduction and somatic maintenance. However, germline maintenance in itself can be costly, and the costs can vary between the sexes depending on the number of gametes produced across the lifetime. We tested this directly by germline ablation using glp-1 RNA interference (RNAi) in a dioecious nematode Caenorhabditis remanei. Germline removal strongly increased heat-shock resistance in both sexes, thus confirming the role of the germline in regulating somatic maintenance. However, germline removal resulted in increased lifespan only in males. High costs of mating strongly reduced lifespan in both sexes and obliterated the survival benefit of germline-less males even though neither sex produced any offspring. Furthermore, germline removal reduced male growth before maturation but not in adulthood, while female growth rate was reduced both before and especially after maturation. Thus, germline removal improves male lifespan without major growth costs, while germline-less females grow slower and do not live longer than reproductively functional counterparts in the absence of environmental stress. Overall, these results suggest that germline maintenance is costlier for males than for females in C. remanei. © 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Mautz, Brian S.Uppsala University, Uppsala, Sweden; Johnson & Johnson, Spring House, Pennsylvania, USA
(författare)
-
Carlsson, HanneUppsala University, Uppsala, Sweden; University of East Anglia, Norwich, United Kingdom
(författare)
-
Hinas, AndreaUppsala University, Uppsala, Sweden
(författare)
-
Gudmunds, ErikUppsala University, Uppsala, Sweden
(författare)
-
Maklakov, Alexei A.Animal Ecology, Department of Ecology and Genetics Uppsala University Uppsala Sweden;School of Biological Sciences University of East Anglia Norwich UK
(författare)
-
Högskolan i HalmstadAkademin för företagande, innovation och hållbarhet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Aging CellChichester : Wiley-Blackwell1474-97181474-9726
Internetlänk
Hitta via bibliotek
Till lärosätets databas