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A role for Hemolect...
A role for Hemolectin in coagulation and immunity in Drosophila melanogaster
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- Lesch, Christine (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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- Goto, Akira (author)
- UPR9022 du CNRS, IBMC, Strasbourg, France
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- Lindgren, Malin (author)
- Södertörns högskola,Institutionen för livsvetenskaper
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- Bidla, Gawa (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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- Dushay, Mitchell S. (author)
- Södertörns högskola,Uppsala universitet,Jämförande fysiologi,Institutionen för livsvetenskaper,Uppsala University
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- Theopold, Ulrich (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Developmental and Comparative Immunology. - : Elsevier BV. - 0145-305X .- 1879-0089. ; 31:12, s. 1255-1263
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Hemolectin has been identified as a candidate clotting factor in Drosophila. We reassessed the domain structure of Hemolectin (Hml) and propose that instead of C-type lectin domains, the two discoidin domains are most likely responsible for the protein's lectin activity. We also tested Hml's role in coagulation and immunity in Drosophila. Here we describe the isolation of a new hml allele in a forward screen for coagulation mutants, and our characterization of this and two other hml alleles, one of which is a functional null. While loss of Hml had strong effects on larval hemolymph coagulation ex vivo, mutant larvae survived wounding. Drosophila thus possesses redundant hemostatic mechanisms. We also found that loss of Hml in immune-handicapped adults rendered them more sensitive to Gram(-) bacteria infection. This demonstrates an immunological role of this clotting protein and reinforces the importance of the clot in insect immunity.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- insect immunity
- innate immunity
- hemolymph coagulation
- discoidin
- lectin
- Biology
- Biologi
- Molecular biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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