Genome-wide association study identifies three new melanoma susceptibility loci

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MARC

Fältnamn	Indikatorer	Metadata
000		06724naa a2201249 4500
001		oai:lup.lub.lu.se:a377bfc7-3220-4e86-aa3b-acc8b4b00ab7
003		SwePub
008		160401s2011 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:123530969
024	7	a https://lup.lub.lu.se/record/22542032 URI
024	7	a https://doi.org/10.1038/ng.9592 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1235309692 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Barrett, Jennifer H.u Karolinska Institutet4 aut
245	1 0	a Genome-wide association study identifies three new melanoma susceptibility loci
264		c 2011-10-09
264	1	b Springer Science and Business Media LLC,c 2011
520		a We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10(-5) and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10(-3): an SNP in ATM (rs1801516, overall P = 3.4 x 10(-9)), an SNP in MX2 (rs45430, P = 2.9 x 10-9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 x 10(-10)). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 x 10(-7) under a fixed-effects model and P = 1.2 x 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Iles, Mark M.4 aut
700	1	a Harland, Mark4 aut
700	1	a Taylor, John C.4 aut
700	1	a Aitken, Joanne F.4 aut
700	1	a Andresen, Per Arne4 aut
700	1	a Akslen, Lars A.4 aut
700	1	a Armstrong, Bruce K.4 aut
700	1	a Avril, Marie-Francoise4 aut
700	1	a Azizi, Esther4 aut
700	1	a Bakker, Bert4 aut
700	1	a Bergman, Wilma4 aut
700	1	a Bianchi-Scarra, Giovanna4 aut
700	1	a Bressac-de Paillerets, Brigitte4 aut
700	1	a Calista, Donato4 aut
700	1	a Cannon-Albright, Lisa A.4 aut
700	1	a Corda, Eve4 aut
700	1	a Cust, Anne E.4 aut
700	1	a Debniak, Tadeusz4 aut
700	1	a Duffy, David4 aut
700	1	a Dunning, Alison M.4 aut
700	1	a Easton, Douglas F.4 aut
700	1	a Friedman, Eitan4 aut
700	1	a Galan, Pilar4 aut
700	1	a Ghiorzo, Paola4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Hansson, Johan4 aut
700	1	a Hocevar, Marko4 aut
700	1	a Hoeiom, Veronicau Karolinska Institutet4 aut
700	1	a Hopper, John L.4 aut
700	1	a Ingvar, Christianu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-cin
700	1	a Janssen, Bart4 aut
700	1	a Jenkins, Mark A.4 aut
700	1	a Jönsson, Göran Bu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-gjo
700	1	a Kefford, Richard F.4 aut
700	1	a Landi, Giorgio4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Lang, Julie4 aut
700	1	a Lubinski, Jan4 aut
700	1	a Mackie, Rona4 aut
700	1	a Malvehy, Josep4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Molven, Anders4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a van Nieuwpoort, Frans A.4 aut
700	1	a Novakovic, Srdjan4 aut
700	1	a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
700	1	a Pastorino, Lorenza4 aut
700	1	a Puig, Susana4 aut
700	1	a Puig-Butille, Joan Anton4 aut
700	1	a Randerson-Moor, Juliette4 aut
700	1	a Snowden, Helen4 aut
700	1	a Tuominen, Raineru Karolinska Institutet4 aut
700	1	a VanBelle, Patricia4 aut
700	1	a van der Stoep, Nienke4 aut
700	1	a Whiteman, David C.4 aut
700	1	a Zelenika, Diana4 aut
700	1	a Han, Jiali4 aut
700	1	a Fang, Shenying4 aut
700	1	a Lee, Jeffrey E.4 aut
700	1	a Wei, Qingyi4 aut
700	1	a Lathrop, G. Mark4 aut
700	1	a Gillanders, Elizabeth M.4 aut
700	1	a Brown, Kevin M.4 aut
700	1	a Goldstein, Alisa M.4 aut
700	1	a Kanetsky, Peter A.4 aut
700	1	a Mann, Graham J.4 aut
700	1	a MacGregor, Stuart4 aut
700	1	a Elder, David E.4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Hayward, Nicholas K.4 aut
700	1	a Gruis, Nelleke A.4 aut
700	1	a Demenais, Florence4 aut
700	1	a Bishop, Julia A. Newton4 aut
700	1	a Bishop, D. Timothy4 aut
710	2	a Karolinska Institutetb Kirurgi, Lund4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 43:11, s. 1108-1113q 43:11<1108-1113x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.959y FULLTEXT
856	4	u https://europepmc.org/articles/pmc3251256?pdf=render
856	4 8	u https://lup.lub.lu.se/record/2254203
856	4 8	u https://doi.org/10.1038/ng.959
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:123530969

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By the author/editor: Barrett, Jennife ...; Iles, Mark M.; Harland, Mark; Taylor, John C.; Aitken, Joanne F ...; Andresen, Per Ar ...; show more...; Akslen, Lars A.; Armstrong, Bruce ...; Avril, Marie-Fra ...; Azizi, Esther; Bakker, Bert; Bergman, Wilma; Bianchi-Scarra, ...; Bressac-de Paill ...; Calista, Donato; Cannon-Albright, ...; Corda, Eve; Cust, Anne E.; Debniak, Tadeusz; Duffy, David; Dunning, Alison ...; Easton, Douglas ...; Friedman, Eitan; Galan, Pilar; Ghiorzo, Paola; Giles, Graham G.; Hansson, Johan; Hocevar, Marko; Hoeiom, Veronica; Hopper, John L.; Ingvar, Christia ...; Janssen, Bart; Jenkins, Mark A.; Jönsson, Göran B; Kefford, Richard ...; Landi, Giorgio; Landi, Maria Ter ...; Lang, Julie; Lubinski, Jan; Mackie, Rona; Malvehy, Josep; Martin, Nicholas ...; Molven, Anders; Montgomery, Gran ...; van Nieuwpoort, ...; Novakovic, Srdja ...; Olsson, Håkan; Pastorino, Loren ...; Puig, Susana; Puig-Butille, Jo ...; Randerson-Moor, ...; Snowden, Helen; Tuominen, Rainer; VanBelle, Patric ...; van der Stoep, N ...; Whiteman, David ...; Zelenika, Diana; Han, Jiali; Fang, Shenying; Lee, Jeffrey E.; Wei, Qingyi; Lathrop, G. Mark; Gillanders, Eliz ...; Brown, Kevin M.; Goldstein, Alisa ...; Kanetsky, Peter ...; Mann, Graham J.; MacGregor, Stuar ...; Elder, David E.; Amos, Christophe ...; Hayward, Nichola ...; Gruis, Nelleke A ...; Demenais, Floren ...; Bishop, Julia A. ...; Bishop, D. Timot ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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