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FältnamnIndikatorerMetadata
00006109naa a2200469 4500
001oai:DiVA.org:umu-187455
003SwePub
008210913s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1874552 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-21-01392 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hathaway, Cassandra A.u Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States4 aut
2451 0a Prolactin and risk of epithelial ovarian cancer
264 1b American Association for Cancer Research (AACR),c 2021
338 a print2 rdacarrier
520 a Background: Prolactin is synthesized in the ovaries and may play a role in ovarian cancer etiology. One prior prospective study observed a suggestive positive association between prolactin levels and risk of ovarian cancer.Methods: Weconducted a pooled case-control study of 703 cases and 864 matched controls nested within five prospective cohorts. We used unconditional logistic regression to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between prolactin and ovarian cancer risk. We examined heterogeneity by menopausal status at blood collection, body mass index (BMI), age, and histotype.Results: Among women with known menopausal status, we observed a positive trend in the association between prolactin and ovarian cancer risk (Ptrend = 0.045; OR, quartile 4 vs. 1 = 1.34; 95% CI = 0.97–1.85), but no significant association was observed for premenopausal or postmenopausal women individually (corresponding OR = 1.38; 95% CI = 0.74–2.58; Ptrend = 0.32 and OR = 1.41; 95% CI = 0.93–2.13; Ptrend = 0.08, respectively; Pheterogeneity = 0.91). In stratified analyses, we observed a positive association between prolactin and risk for women with BMI ≥ 25 kg/m2, but not BMI < 25 kg/m2 (corresponding OR = 2.68; 95% CI = 1.56–4.59; Ptrend < 0.01 and OR = 0.90; 95% CI = 0.58–1.40; Ptrend = 0.98, respectively; Pheterogeneity < 0.01). Associations did not vary by age, postmenopausal hormone therapy use, histotype, or time between blood draw and diagnosis.Conclusions: We found a trend between higher prolactin levels and increased ovarian cancer risk, especially among women with a BMI ≥ 25 kg/m2.Impact: This work supports a previous study linking higher prolactin with ovarian carcinogenesis in a high adiposity setting. Future work is needed to understand the mechanism underlying this association.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Rice, Megan S.u Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States4 aut
7001 a Townsend, Mary K.u Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States4 aut
7001 a Hankinson, Susan E.u Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, MA, Amherst, United States4 aut
7001 a Arslan, Alan A.u Department of Obstetrics and Gynecology, New York University Langone Health, NY, New York, United States; Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States4 aut
7001 a Buring, Julie E.u Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut
7001 a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002
7001 a Kubzansky, Laura D.u Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut
7001 a Lee, I-Minu Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut
7001 a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001
7001 a Sluss, Patrick M.u Department of Pathology, Massachusetts General Hospital, MA, Boston, United States4 aut
7001 a Zeleniuch-Jacquotte, Anneu Department of Population Health, New York University Langone Health, NY, New York, United States; NYU Perlmutter Comprehensive Cancer Center, NY, New York, United States4 aut
7001 a Tworoger, Shelley S.u Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut
7102 a Department of Cancer Epidemiology, Moffitt Cancer Center, FL, Tampa, United Statesb Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, MA, Boston, United States4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Research (AACR)g 30:9, s. 1652-1659q 30:9<1652-1659x 1055-9965x 1538-7755
8564 u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419083/y PMC free full text
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187455
8564 8u https://doi.org/10.1158/1055-9965.EPI-21-0139

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