Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Jin Zhen) > Effects of GABA(B) ...

Wu, NanNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)

Effects of GABA(B) receptors in the insula on recognition memory observed with intellicage

Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

2017-04-17
Springer Science and Business Media LLC,2017
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-322808
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322808URI
https://doi.org/10.1186/s12993-017-0125-4DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Background: Insular function has gradually become a topic of intense study in cognitive research. Recognition memory is a commonly studied type of memory in memory research. GABA(B)R has been shown to be closely related to memory formation. In the present study, we used intellicage, which is a new intelligent behavioural test system, and a bilateral drug microinjection technique to inject into the bilateral insula, to examine the relationship between GABA(B)R and recognition memory. Methods: Male Sprague- Dawley rats were randomly divided into control, Sham, Nacl, baclofen and CGP35348 groups. Different testing procedures were employed using intellicage to detect changes in rat recognition memory. The expression of GABA(B)R (GB1, GB2) in the insula of rats was determined by immunofluorescence and western blotting at the protein level. In addition, the expression of GABA(B)R (GB1, GB2) was detected by RT-PCR at the mRNA level. Results: The results of the intellicage test showed that recognition memory was impaired in terms of position learning, punitive learning and punitive reversal learning by using baclofen and CGP35348. In position reversal learning, no significant differences were found in terms of cognitive memory ability between the control groups and the CGP and baclofen groups. Immunofluorescence data showed GABA(B)R (GB1, GB2) expression in the insula, while data from RTPCR and western blot analysis demonstrated that the relative expression of GB1 and GB2 was significantly increased in the baclofen group compared with the control groups. In the CGP35348 group, the expression of GB1 and GB2 was significantly decreased, but there was no significant difference in GB1 or GB2 expression in the control groups. Conclusions: GABA(B)R expression in the insula plays an important role in the formation of recognition memory in rats.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
GABA(B)R
Insula
Recognition of memory
Intellicage

Biuppslag (personer, institutioner, konferenser, titlar ...)

Wang, FengNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)
Jin, ZheUppsala universitet,Fysiologi(Swepub:uu)zheji315 (författare)
Zhang, ZhenNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)
Wang, Lian-KunNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)
Zhang, ChunNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)
Sun, TaoNingxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China. (författare)
Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Ningxia, Peoples R China.;Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Ningxia, Peoples R China.Fysiologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Behavioral and Brain Functions: Springer Science and Business Media LLC13:71744-9081

Internetlänk

Hitta via bibliotek

Behavioral and Brain Functions (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Wu, Nan; Wang, Feng; Jin, Zhe; Zhang, Zhen; Wang, Lian-Kun; Zhang, Chun; visa fler...; Sun, Tao; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Artiklar i publikationen: Behavioral and B ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se