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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12260naa a2203157 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:149216248 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:cb5200c2-6bbe-4791-a554-0d6bd6c5ee64 | |
| 009 | oai:gup.ub.gu.se/315469 | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1492162482 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-022-04554-y2 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/cb5200c2-6bbe-4791-a554-0d6bd6c5ee642 URI |
| 024 | 7 | a https://gup.ub.gu.se/publication/3154692 URI |
| 040 | a (SwePub)kid (SwePub)lud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bethlehem, RAIu University of Cambridge4 aut |
| 245 | 1 0 | a Brain charts for the human lifespan |
| 264 | c 2022-04-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
| 653 | a anatomy and histology | |
| 653 | a body height | |
| 653 | a brain | |
| 653 | a human | |
| 653 | a longevity | |
| 653 | a neuroimaging | |
| 653 | a nuclear magnetic resonance imaging | |
| 653 | a procedures | |
| 653 | a Body Height | |
| 653 | a Brain | |
| 653 | a Humans | |
| 653 | a Longevity | |
| 653 | a Magnetic Resonance Imaging | |
| 653 | a Neuroimaging | |
| 653 | a psychiatric-disorders | |
| 653 | a cortical thickness | |
| 653 | a white-matter | |
| 653 | a growth | |
| 653 | a organization | |
| 653 | a association | |
| 653 | a disease | |
| 653 | a mri | |
| 653 | a burden | |
| 653 | a models | |
| 653 | a Science & Technology - Other Topics | |
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| 700 | 1 | a Hammill, CF4 aut |
| 700 | 1 | a Hansson, O.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ohn |
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| 700 | 1 | a Kawashima, R4 aut |
| 700 | 1 | a Kelley, EA4 aut |
| 700 | 1 | a Kern, Silkeu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology,Centre for Ageing and Health (Agecap)4 aut0 (Swepub:gu)xkersi |
| 700 | 1 | a Kim, KW4 aut |
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| 700 | 1 | a Morgan, SE4 aut |
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| 700 | 1 | a Ortinau, C4 aut |
| 700 | 1 | a Ossenkoppele, R.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)ri1513os |
| 700 | 1 | a Ouyang, M4 aut |
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| 700 | 1 | a Shinohara, RT4 aut |
| 700 | 1 | a Skoog, Ingmar,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology,Centre for Ageing and Health (Agecap)4 aut0 (Swepub:gu)xskooi |
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| 700 | 1 | a R, Brain4 aut |
| 710 | 2 | a University of Cambridgeb The Children's Hospital of Philadelphia4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 604:79057906, s. 525-+q 604:79057906<525-+x 1476-4687x 0028-0836 |
| 856 | 4 | u http://dx.doi.org/10.1038/s41586-022-04554-yx freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149216248 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-022-04554-y |
| 856 | 4 8 | u https://lup.lub.lu.se/record/cb5200c2-6bbe-4791-a554-0d6bd6c5ee64 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/315469 |
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