WFRF:(Naidu P.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 11076naa a2200949 4500 | |
| 001 | oai:gup.ub.gu.se/310867 | |
| 003 | SwePub | |
| 008 | 240910s2021 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:oru-95586 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3108672 URI |
| 024 | 7 | a https://doi.org/10.1038/s41564-021-01000-z2 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-955862 URI |
| 040 | a (SwePub)gud (SwePub)oru | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Beale, M. A.u Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK,Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK,STI Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Hospital Vall d'Hebron, Barcelona, Spain4 aut |
| 245 | 1 0 | a Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis |
| 264 | c 2021-11-24 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 500 | a Funding agencies:National Health and Medical Research Council of Australia 1174555 United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) R01 AI123196 UK Research & Innovation (UKRI)Medical Research Council UK (MRC) MR/V027956/1 United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA R01 AI42143DH | NIHR | Programme Development Grants (NIHR Programme Development Grants) NIHR200125 European and Developing Countries Clinical Trials Partnership (EDCTP) RIA2018D-249 | |
| 520 | a Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. pallidum, has an estimated 6.3 million cases worldwide per annum. In the past ten years, the incidence of syphilis has increased by more than 150% in some high-income countries, but the evolution and epidemiology of the epidemic are poorly understood. To characterize the global population structure of T. pallidum, we assembled a geographically and temporally diverse collection of 726 genomes from 626 clinical and 100 laboratory samples collected in 23 countries. We applied phylogenetic analyses and clustering, and found that the global syphilis population comprises just two deeply branching lineages, Nichols and SS14. Both lineages are currently circulating in 12 of the 23 countries sampled. We subdivided T. p.pallidum into 17 distinct sublineages to provide further phylodynamic resolution. Importantly, two Nichols sublineages have expanded clonally across 9 countries contemporaneously with SS14. Moreover, pairwise genome analyses revealed examples of isolates collected within the last 20 years from 14 different countries that had genetically identical core genomes, which might indicate frequent exchange through international transmission. It is striking that most samples collected before 1983 are phylogenetically distinct from more recently isolated sublineages. Using Bayesian temporal analysis, we detected a population bottleneck occurring during the late 1990s, followed by rapid population expansion in the 2000s that was driven by the dominant T. pallidum sublineages circulating today. This expansion may be linked to changing epidemiology, immune evasion or fitness under antimicrobial selection pressure, since many of the contemporary syphilis lineages we have characterized are resistant to macrolides. Global syphilis prevalence has been increasing. Sequencing and analysis of a global collection of 726 Treponema pallidum samples reveal globally circulating lineages linked to a rapid expansion occurring since the end of the twentieth century. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng |
| 653 | a molecular clock | |
| 653 | a r package | |
| 653 | a selection | |
| 653 | a yaws | |
| 653 | a recombination | |
| 653 | a visualization | |
| 653 | a epidemiology | |
| 653 | a algorithm | |
| 653 | a sequence | |
| 653 | a strains | |
| 653 | a Microbiology | |
| 700 | 1 | a Marks, M.u The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia4 aut |
| 700 | 1 | a Cole, M. J.u HCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, UK4 aut |
| 700 | 1 | a Lee, M. K.u British Columbia Centre for Disease Control, Public Health Laboratory, Vancouver, British Columbia, Canada; Clinical Microbiology Department, Queen Elizabeth Hospital, Birmingham, UK4 aut |
| 700 | 1 | a Pitt, R.u HCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, UK4 aut |
| 700 | 1 | a Ruis, C.u Molecular Immunity Unit, MRC-Laboratory of Molecular Biology, Department of Medicine, University of Cambridge, Cambridge, UK; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK,Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium4 aut |
| 700 | 1 | a Balla, E.u Bacterial STIs Reference Laboratory, Department of Bacteriology, National Public Health Centre, Budapest, Hungary4 aut |
| 700 | 1 | a Crucitti, T.u Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium4 aut |
| 700 | 1 | a Ewens, M.u Brotherton Wing, Leeds General Infirmary, Leeds, UK4 aut |
| 700 | 1 | a Fernandez-Naval, C.u Microbiology Department, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain4 aut |
| 700 | 1 | a Grankvist, A.u National Reference Laboratory for STIs, Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut |
| 700 | 1 | a Guiver, M.u Laboratory Network, Manchester, UK Health Security Agency, Manchester Royal Infirmary, Manchester, UK,British Columbia Centre for Disease Control, Public Health Laboratory, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada4 aut |
| 700 | 1 | a Kenyon, C. R.u Colorado School of Public Health, University of Colorado, Denver, CO, USA4 aut |
| 700 | 1 | a Khairullin, R.u Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia4 aut |
| 700 | 1 | a Kularatne, R.u Centre for HIV and STI, National Institute for Communicable Diseases, Johannesburg, South Africa4 aut |
| 700 | 1 | a Arando, M.4 aut |
| 700 | 1 | a Molini, B. J.u Department of Medicine, University of Washington, Seattle, WA, USA4 aut |
| 700 | 1 | a Obukhov, A.u Tuvan Republican Skin and Venereal Diseases Dispensary, Ministry of Health of Tuva Republic, Kyzyl, Russia4 aut |
| 700 | 1 | a Page, E. E.u Virology Department, Old Medical School, Leeds Teaching Hospitals Trust, Leeds, UK4 aut |
| 700 | 1 | a Petrovay, F.u Bacterial STIs Reference Laboratory, Department of Bacteriology, National Public Health Centre, Budapest, Hungary4 aut |
| 700 | 1 | a Rietmeijer, C.4 aut |
| 700 | 1 | a Rowley, D.u Midlands Regional Hospital Portlaoise, Laois, Ireland4 aut |
| 700 | 1 | a Shokoples, S.u Alberta Precision Laboratories, Edmonton, Alberta, Canada4 aut |
| 700 | 1 | a Smit, E.u Clinical Microbiology Department, Queen Elizabeth Hospital, Birmingham, UK; Institute of Environmental Science and Research, Wellington, New Zealand4 aut |
| 700 | 1 | a Sweeney, E. L.u The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia4 aut |
| 700 | 1 | a Taiaroa, G.u Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia4 aut |
| 700 | 1 | a Vera, J. H.u Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK4 aut |
| 700 | 1 | a Wennerås, Christine,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,National Reference Laboratory for STIs, Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:gu)xwennc |
| 700 | 1 | a Whiley, D. M.4 aut |
| 700 | 1 | a Williamson, D. A.u Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia4 aut |
| 700 | 1 | a Hughes, G.u Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK4 aut |
| 700 | 1 | a Naidu, P.u Alberta Precision Laboratories, Edmonton, Alberta, Canada; Department of Laboratory Medicine and Pathology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada4 aut |
| 700 | 1 | a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for STIs, Faculty of Medicine and Health4 aut0 (Swepub:oru)muo |
| 700 | 1 | a Krajden, M.4 aut |
| 700 | 1 | a Lukehart, S. A.u Departments of Medicine/Infectious Diseases and Global Health, University of Washington, Seattle, WA, USA4 aut |
| 700 | 1 | a Morshed, M. G.4 aut |
| 700 | 1 | a Fifer, H.u Blood Safety, Hepatitis, STI and HIV Division, UK Health Security Agency, London, UK4 aut |
| 700 | 1 | a Thomson, N. R.u Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK4 aut |
| 710 | 2 | a Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UKb Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK4 org |
| 773 | 0 | t Nature Microbiologyd : Springer Science and Business Media LLCg 6:12q 6:12x 2058-5276 |
| 856 | 4 | u https://www.nature.com/articles/s41564-021-01000-z.pdf |
| 856 | 4 | u https://doi.org/10.1038/s41564-021-01000-zy Fulltext |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/310867 |
| 856 | 4 8 | u https://doi.org/10.1038/s41564-021-01000-z |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95586 |
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