WFRF:(Rydberg Lennart 1944)
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Antibody response in an ABO-incompatible blood transfusion. Antigen specificity and immunoglobulin class.
- Rydberg, Lennart, 1944 (author)
-
- Breimer, Michael, 1951 (author)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
- Samuelsson, B E (author)
- (creator_code:org_t)
- 1988
- 1988
- English.
- In: Transfusion. - 0041-1132. ; 28:5, s. 483-8
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The anti-A response in a group B patient accidentally given 1 unit transfusion of A1 blood is described. The antibody response is characterized both with conventional agglutination techniques and with radioimmunoassay using pure group A antigens with different core saccharide structures (type 1, 2, and 4 chains) and class-specific second antibodies. The anti-A titer rose to a maximum Days 11 to 14 after the incompatible transfusion. The antibodies involved were mainly of the IgG and IgA types, while the IgM response was moderate. The IgA antibodies seemed to be nonselective with respect to group A antigen type, while the IgG antibodies showed a specificity against type 2 chain group A antigens.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- ABO Blood-Group System
- Aged
- Antibody Formation
- Blood Group Incompatibility
- blood
- Blood Transfusion
- Epitopes
- Humans
- Immunoglobulins
- classification
- Isoantigens
- immunology
- Male
- Radioimmunoassay
Publication and Content Type
- ref (subject category)
- art (subject category)
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