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Normal tissue response to low doses of radiotherapy assessed by molecular markers--a study of skin in patients treated for prostate cancer.

Turesson, I (författare)
Bernefors, R (författare)
Book, M (författare)
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Flogegård, M (författare)
Hermansson, I (författare)
Johansson, Karl-Axel (författare)
Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för radiofysik,Institute of Selected Clinical Sciences, Department of Radiation Physics
Lindh, A (författare)
Sigurdardottir, S (författare)
Thunberg, U (författare)
Nyman, Jan, 1956 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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 (creator_code:org_t)
2001
2001
Engelska.
Ingår i: Acta oncologica (Stockholm, Sweden). - 0284-186X. ; 40:8, s. 941-51
Relaterad länk:
https://gup.ub.gu.se...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The aim of this study was to evaluate normal tissue response by molecular markers to multifraction low doses of ionizing radiation, with the focus on changes in repopulation, estimated using Ki-67 as the proliferation marker, and on expressions of the p53 and p21 proteins, identified as key proteins in the DNA damage checkpoint. Repeated skin biopsies were taken from patients treated for prostate cancer with radiotherapy. The expressions of Ki-67, p53 and p21 of the keratinocytes in the basal cell layer of the epidermis were quantified immunohistochemically. The dose to the basal layer was 1.1 Gy per fraction, given five times per week for seven weeks. The indices of the three markers were determined over the whole period. A significant suppression of the Ki-67 index was observed during the first weeks, followed by a significant gradual increase in the Ki-67 index over the last weeks. The p53 and p21 protein levels were almost zero in the unirradiated skin. Upon irradiation, both the p53 and p21 index increased in a pattern very congruent to the Ki-67 index. In conclusion, daily fractions of about 1 Gy to the skin resulted in, for the keratinocytes in the basal layer, a cell growth arrest for a couple of weeks and a subsequent acceleration in repopulation during the following weeks of irradiation. The present findings also provided novel insights into the role of the p53/p21 pathway in the response of a normal epithelium to ionizing radiation as it is applied in radiotherapy.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Biological Markers
analysis
Biopsy
DNA Damage
Humans
Immunohistochemistry
Ki-67 Antigen
analysis
biosynthesis
Male
Prostatic Neoplasms
pathology
radiotherapy
Proto-Oncogene Proteins p21(ras)
analysis
biosynthesis
Radiation Injuries
diagnosis
physiopathology
Skin
pathology
radiation effects
Tumor Suppressor Protein p53
analysis
biosynthesis

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