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PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9) : Novel Biomarkers for Preeclampsia

Kandel, Manju (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.
MacDonald, Teresa M. (author)
Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
Walker, Susan P. (author)
Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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Cluver, Catherine (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.;Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
Bergman, Lina (author)
Uppsala universitet,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.;Univ Gothenburg, Inst Clin Sci, Dept Obstet & Gynecol, Sahlgrenska Acad, Gothenburg, Sweden.
Myers, Jenny (author)
Univ Manchester, Div Dev Biol & Med, Manchester Acad Hlth Sci Ctr, St Marys Hosp, Manchester, Lancs, England.
Hastie, Roxanne (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.
Keenan, Emerson (author)
Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.
Hannan, Natalie J. (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
Cannon, Ping (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.
Nguyen, Tuong-Vi (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.
Pritchard, Natasha (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
Tong, Stephen (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
Kaitu'u-Lino, Tu'uhevaha J. (author)
Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia.;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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Mercy Hosp Women, Anslat Obstet Gr, Heidelberg, Vic, Australia;Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia. Univ Melbourne, Dept Obstet & Gynaecol, Mercy Hosp Women, 163 Studley Rd, Heidelberg, Vic 3084, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia. (creator_code:org_t)
Ovid Technologies (Wolters Kluwer Health), 2022
2022
English.
In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 11:7
Related links:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background: Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomarkers are lacking. We evaluated the biomarker potential, expression, and function of PSG7 (pregnancy-specific beta-1 glycoprotein 7) and PSG9 (pregnancy-specific beta-1 glycoprotein 9) in preeclampsia.Methods and Results: At 36 weeks gestation preceding term preeclampsia diagnosis, PSG7 and PSG9 (in Australian cohorts of n=918 and n=979, respectively) were significantly increased before the onset of term preeclampsia (PSG7, P=0.013; PSG9, P=0.0011). In samples collected at 28 to 32 weeks from those with preexisting cardiovascular disease and at high risk of preeclampsia (Manchester Antenatal Vascular Service, UK cohort, n=235), both PSG7 and PSG9 were also significantly increased preceding preeclampsia onset (PSG7, P<0.0001; PSG9, P=0.0003) relative to controls. These changes were validated in the plasma and placentas of patients with established preeclampsia who delivered at <34 weeks gestation (PSG7, P=0.0008; PSG9, P<0.0001). To examine whether PSG7 and PSG9 are associated with increasing disease severity, we measured them in a cohort from South Africa stratified for this outcome, the PROVE (Preeclampsia Obstetric Adverse Events) cohort (n=72). PSG7 (P=0.0027) and PSG9 (P=0.0028) were elevated among patients who were preeclamptic with severe features (PROVE cohort), but not significantly changed in those without severe features or with eclampsia. In syncytialized first trimester cytotrophoblast stem cells, exposure to TNF alpha (tumor necrosis factor alpha) or IL-6 (interleukin 6) significantly increased the expression and secretion of PSG7 and PSG9. In contrast, when we treated primary endothelial cells with recombinant PSG7 and PSG9, we only observed modest changes in Flt-1 (FMS-like tyrosine kinase-1) expression and Plgf (placental growth factor) expression, and no other effects on proangiogenic/antiangiogenic or endothelial dysfunction markers were observed.Conclusions: Circulating PSG7 and PSG9 are increased before preeclampsia onset and among those with established disease with their production and release potentially driven by placental inflammation.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Keyword

biomarkers
placenta
preeclampsia
pregnancy
pregnancy specific beta-1 glycoproteins

Publication and Content Type

ref (subject category)
art (subject category)

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