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Compositional and f...
Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals
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- Vaga, S. (author)
- King's College London
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- Lee, S. (author)
- King's College London
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- Ji, Boyang, 1983 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Andreasson, Anna (author)
- Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Macquarie University, Australia; Karolinska Institutet, Sweden
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- Talley, N. J. (author)
- University of Newcastle
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- Agreus, L. (author)
- Karolinska Institutet
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- Bidkhori, G. (author)
- King's College London
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- Kovatcheva-Datchary, Petia (author)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg
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- Park, J. (author)
- Korea Advanced Institute of Science and Technology (KAIST)
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- Lee, D. (author)
- Korea Advanced Institute of Science and Technology (KAIST)
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- Proctor, G. (author)
- King's College London
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- Shoaie, Saeed (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Engstrand, L. (author)
- Karolinska Institutet
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Shoaie, S. (author)
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(creator_code:org_t)
- 2020-09-11
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Abstract
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- Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as most studies have employed sequencing technologies to investigate faecal microbiota only. This work used shotgun metagenomics of mucosal biopsies to explore the microbial communities' compositions of terminal ileum and large intestine in 5 healthy individuals. Functional annotations and genome-scale metabolic modelling of selected species were then employed to identify local functional enrichments. While faecal metagenomics provided a good approximation of the average gut mucosal microbiome composition, mucosal biopsies allowed detecting the subtle variations of local microbial communities. Given their significant enrichment in the mucosal microbiota, we highlight the roles of Bacteroides species and describe the antimicrobial resistance biogeography along the intestine. We also detail which species, at which locations, are involved with the tryptophan/indole pathway, whose malfunctioning has been linked to pathologies including inflammatory bowel disease. Our study thus provides invaluable resources for investigating mechanisms connecting gut microbiota and host pathophysiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- irritable-bowel-syndrome
- gut microbiome
- tryptophan-metabolism
- genetic-determinants
- bacteroides
- bacterial
- patterns
- impact
- cells
- kegg
- Science & Technology - Other Topics
- gut mucosal microbes
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vaga, S.
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Lee, S.
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Ji, Boyang, 1983
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Andreasson, Anna
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Talley, N. J.
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Agreus, L.
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show more...
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Bidkhori, G.
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Kovatcheva-Datch ...
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Park, J.
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Lee, D.
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Proctor, G.
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Shoaie, Saeed
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Nielsen, Jens B, ...
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Engstrand, L.
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Shoaie, S.
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- By the university
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University of Gothenburg
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Chalmers University of Technology
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Stockholm University
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Royal Institute of Technology
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Karolinska Institutet