Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8(+) T cells in HIV/TB co-infection

Search: L773:0008 8749 > Concurrent loss of ...

Larsson, Marie (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten

Shankar, Esaki M. (author): University of Malaya, Malaysia; University of Malaya, Malaysia; University of Malaya, Malaysia

(creator_code:org_t)

ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015
2015
English.
In: Cellular Immunology. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0008-8749 .- 1090-2163. ; 297:1, s. 19-32

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

The role of T-cell immunosenescence and functional CD8(+) T-cell responses in HIV/TB co-infection is unclear. We examined and correlated surrogate markers of HIV disease progression with immune activation, immunosenescence and differentiation using T-cell pools of HIV/TB co-infected, HIV-infected and healthy controls. Our investigations showed increased plasma viremia and reduced CD4/CD8 T-cell ratio in HIV/TB co-infected subjects relative to HIV-infected, and also a closer association with changes in the expression of CD38, a cyclic ADP ribose hydrolase and CD57, which were consistently expressed on late-senescent CD8(+) T cells. Up-regulation of CD57 and CD38 were directly proportional to lack of co-stimulatory markers on CD8(+) T cells, besides diminished expression of CD127 (IL-7R alpha) on CD57(+)CD4(+) T cells. Notably, intracellular IFN-gamma, perforin and granzyme B levels in HIV-specific CD8(+) T cells of HIV/TB co-infected subjects were diminished. Intracellular CD57 levels in HIV gag p24-specific CD8(+) T cells were significantly increased in HIV/TB co-infection. We suggest that HIV-TB co-infection contributes to senescence associated with chronic immune activation, which could be due to functional insufficiency of CD8(+) T cells. (C) 2015 Elsevier Inc. All rights reserved.

By the author/editor: Saeidi, Alireza; Chong, Yee K.; Yong, Yean K.; Tan, Hong Y.; Barathan, Muttia ...; Rajarajeswaran, ...; show more...; Sabet, Negar S.; Sekaran, Shamala ...; Ponnampalavanar, ...; Che, Karlhans F.; Velu, Vijayakuma ...; Kamarulzaman, Ad ...; Larsson, Marie; Shankar, Esaki M ...; show less...

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