Time-of-flight secondary ion mass spectrometric analysis of the interface between bone and titanium implants.

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Time-of-flight secondary ion mass spectrometric analysis of the interface between bone and titanium implants.

Eriksson, Cecilia (författare)

Malmberg, Per, 1974 (författare): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg

Nygren, Håkan, 1952 (författare): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,University of Gothenburg

(creator_code:org_t)

2008-02-27
2008
Engelska.
Ingår i: Rapid communications in mass spectrometry : RCM. - : Wiley. - 0951-4198 .- 1097-0231. ; 22:7, s. 943-9

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://research.cha...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Implant healing into bone tissue is a process where the mature bone grows towards and eventually fuses with the implant. In this study we investigated implant healing during 4 weeks with focus on the implant-tissue interface. Our main interest was to study the mineralization process around the implant. Titanium discs were implanted in rat tibia for 2 and 4 weeks. After implantation cross sections of bone and implant were made using a low-speed saw equipped with a diamond wafering blade. One section from each sample was stained with basic fuchsin and micrographed by light microscopy (LM). The other section was analyzed with imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) using a Bi(3)(+) cluster ion source. This ion source has recently been shown to enable identification of high-mass hydroxyapatite (HA) fragment ions (m/z 291-653) in bone samples. The LM images were used to identify areas suitable for TOF-SIMS analysis. Three areas were selected for mass spectral analysis, corresponding to interface region, bone and soft tissue, from which positive ion spectra were recorded. In the areas identified as bone, high-mass HA fragments ions were found after both 2 and 4 weeks. In the soft tissue area, no high-mass ions were found after 4 weeks. However, after 2 weeks HA-related ions were identified in mineralized spots in areas defined as soft tissue. After 4 but not after 2 weeks, high-mass HA fragment ions were found in the interface region. In conclusion, differences were observed regarding mineralization between 2 and 4 weeks of implantation and between different regions surrounding the implants. Imaging TOF-SIMS analysis using a Bi(3)(+) cluster as ion source enables identification of high-mass HA fragment ions at implant-tissue interfaces in bone. This technique might therefore be useful for biocompatibility assessment and for studying the mineralization process at implant surfaces.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Animals
Calcification
Physiologic
Durapatite
analysis
chemistry
Male
Prostheses and Implants
Rats
Rats
Sprague-Dawley
Spectrometry
Mass
Electrospray Ionization
methods
Spectrometry
Mass
Matrix-Assisted Laser Desorption-Ionization
methods
Surface Properties
Tibia
chemistry
surgery
Tibial Fractures
metabolism
surgery
Titanium
analysis
chemistry
analysis

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Av författaren/redakt...: Eriksson, Cecili ...; Malmberg, Per, 1 ...; Nygren, Håkan, 1 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Biomaterialveten ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

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Av lärosätet: Göteborgs universitet; Chalmers tekniska högskola

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