There is no association between combined oral hormonal contraceptives and depression: a Swedish register-based cohort study

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There is no association between combined oral hormonal contraceptives and depression : a Swedish register-based cohort study

Lundin, C. (författare): Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

Wikman, Anna (författare): Uppsala universitet,Reproduktiv hälsa

Lampa, E. (författare): Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden

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Bixo, Marie (författare): Umeå universitet,Obstetrik och gynekologi

Gemzell-Danielsson, K. (författare): Karolinska Institutet

Wikman, P. (författare): Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

Ljung, R. (författare): Karolinska Institutet

Sundström Poromaa, I. (författare): Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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2021-12-09
2022
Engelska.
Ingår i: British Journal of Obstetrics and Gynecology. - : John Wiley & Sons. - 1470-0328 .- 1471-0528. ; 129:6, s. 917-925

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://onlinelibrar...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Objective: To investigate whether users of hormonal contraceptives (HCs) are at increased risk of depression compared with non-users. Design: Register-based cohort study.Setting: Sweden.Sample: Women aged 15–25 years between 2010 and 2017 with no prior antidepressant treatment, psychiatric diagnose or contraindication for HCs (n = 739 585).Methods: Women with a prescription of HC were identified via the Swedish Prescribed Drug Register (SPDR). Relative risks (RRs) for first depression diagnosis in current HC-users compared with non-users were modelled by Poisson regression. Adjustments included age, medical indication for HC-use and parental history of mental disorders, among others.Main outcome measures: Depression, captured by a redeemed prescription of antidepressant treatment, or a first depression diagnosis in the SPDR and the National Patient Register.Results: Compared with non-users, women on combined oral contraceptives (COCs) and oral progestogen-only products had lower or no increased risk of depression, relative risk (RR) 0.89 (95% CI 0.87–0.91) and 1.03 (95% CI 0.99–1.06) after adjustments, respectively. Age-stratified analyses demonstrated that COC use in adolescents conferred no increase in risk (RR 0.96, 95% CI 0.93–0.98), whereas use of progestogen-only pills (RR 1.13, 95% CI 1.07–1.19), contraceptive patch/vaginal ring (RR 1.43, 95% CI 1.30–1.58), implant (RR 1.38, 95% CI 1.30–1.45) or a levonorgestrel intrauterine device (RR 1.59, 95% CI 1.46–1.73) were associated with increased risks.Conclusions: This study did not find any association between use of COCs, which is the dominating HC in first time users, and depression. Non-oral products were associated with increased risks. Residual confounding must be addressed in the interpretation of the results. Tweetable abstract: There is no association between combined hormonal contraceptives and depression.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Nyckelord

Antidepressant treatment
combined oral contraceptives
depression
hormonal contraceptives
mental effects
pharmaco-epidemiology

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Av författaren/redakt...: Lundin, C.; Wikman, Anna; Lampa, E.; Bixo, Marie; Gemzell-Danielss ...; Wikman, P.; visa fler...; Ljung, R.; Sundström Poroma ...; visa färre...

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Av lärosätet: Umeå universitet; Karolinska Institutet; Uppsala universitet

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