Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden

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Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden

Lopes De Oliveira, Thaís (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet, Stockholm, Sweden

Tang, Bowen (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Bai, Ge (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; epartment of Women's and Children's Health, Uppsala Universitet, Uppsala, Sweden

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Sjölander, Arvid (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Jylhävä, Juulia (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Faculty of Social Sciences (Health Sciences) and Gerontology Research Center (GEREC), University of Tampere, Tampere, Finland

Finkel, Deborah (författare): Jönköping University,HHJ, Institutet för gerontologi,Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA

Pedersen, Nancy L. (författare): Karolinska Institutet

Hassing, Linda B. (författare): Department of Psychology, University of Gothenburg, Gothenburg, Sweden; Centre for Ageing and Health, University of Gothenburg, Gothenburg, Sweden

Reynolds, Chandra A. (författare): Department of Psychology, The University of California at Riverside, Riverside, California, USA; Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA

Karlsson, Ida K (författare): Karolinska Institutet

Hägg, Sara (författare): Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

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2024
2024
Engelska.
Ingår i: Aging Cell. - : John Wiley & Sons. - 1474-9718 .- 1474-9726.

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Antihypertensive, lipid-lowering, and blood glucose-lowering drugs have slowed down the aging process in animal models. In humans, studies are limited, have short follow-up times, and show mixed results. Therefore, this study aimed to estimate the effects of commonly used medications on functional aging, cognitive function, and frailty. We included information on individuals from three Swedish longitudinal population-based studies collected between 1986 and 2014. Our exposures were the 21 most used groups of medications among individuals aged 65 years and older in the Swedish population in 2022. Functional aging index (n = 1191), cognitive function (n = 1094), and frailty index (n = 1361) were the outcomes of interest. To estimate the medication effects, we used a self-controlled analysis, where each individual is his/her own control, thereby adjusting for all time-stable confounders. The analysis was additionally adjusted for time-varying confounders (chronological age, Charlson Comorbidity Index, smoking, body mass index, and the number of drugs). The participants were 65.5-82.8 years at the first in-person assessment. Adrenergics/inhalants (effect size = 0.089) and lipid-modifying agents/plain (effect size = 0.082) were associated with higher values of cognitive function (improvement), and selective calcium channel blockers with mainly vascular effects (effect size = -0.129) were associated with lower values of the functional aging index (improvement). No beneficial effects were found on the frailty index. Adrenergics/inhalants, lipid-modifying agents/plain, and selective calcium channel blockers with mainly vascular effects may benefit functional biomarkers of aging. More research is needed to investigate their clinical value in preventing adverse aging outcomes.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

aging
cognitive function
frailty
medication
physical function

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Av författaren/redakt...: Lopes De Oliveir ...; Tang, Bowen; Bai, Ge; Sjölander, Arvid; Jylhävä, Juulia; Finkel, Deborah; visa fler...; Pedersen, Nancy ...; Hassing, Linda B ...; Reynolds, Chandr ...; Karlsson, Ida K; Hägg, Sara; visa färre...

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Artiklar i publikationen: Aging Cell

Av lärosätet: Jönköping University; Karolinska Institutet

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