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Serum ferritin and ...
Serum ferritin and obstructive sleep apnea-epidemiological study
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- Thorarinsdottir, Elin H. (author)
- Natl Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, Sleep Dept E7, IS-108 Reykjavik, Iceland
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- Arnardottir, Erna S. (author)
- Natl Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, Sleep Dept E7, IS-108 Reykjavik, Iceland
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- Benediktsdottir, Bryndis (author)
- Natl Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, Sleep Dept E7, IS-108 Reykjavik, Iceland
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Olafsson, Isleifur (author)
- Landspitali Natl Univ Hosp Iceland, Dept Clin Biochem, Reykjavik, Iceland
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- Pack, Allan I. (author)
- Univ Penn, Sch Med, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA;Univ Penn, Sch Med, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA
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- Gislason, Thorarinn (author)
- Natl Univ Iceland, Fac Med, Reykjavik, Iceland;Landspitali Natl Univ Hosp Iceland, Sleep Dept E7, IS-108 Reykjavik, Iceland
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- Keenan, Brendan T. (author)
- Univ Penn, Sch Med, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA;Univ Penn, Sch Med, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA
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(creator_code:org_t)
- 2017-12-09
- 2018
- English.
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In: Sleep and Breathing. - : SPRINGER HEIDELBERG. - 1520-9512 .- 1522-1709. ; 22:3, s. 663-672
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- PurposeFerritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positive airway pressure (PAP) on S-Ferritin levels.MethodsThe OSA subjects (n=796) were part of the Icelandic Sleep Apnea Cohort. The control subjects (n=637) were randomly chosen Icelanders who participated in an epidemiological study. Propensity score (PS) methodologies were employed to minimize selection bias and strengthen causal inferences when comparing non-randomized groups. S-Ferritin levels were measured and all participants answered the same detailed questionnaire about sleep and health. Only OSA patients underwent a sleep study and were re-invited for a 2-year follow-up.ResultsS-Ferritin levels were significantly higher in OSA males than controls (213.3 vs. 197.3g/L, p=0.007). However, after adjusting for confounders and using our PS methodology, no significant difference was found. S-Ferritin levels were not correlated with severity of OSA, obesity level, or clinical symptoms. Also, no significant change in S-Ferritin levels was found with 2years of PAP treatment.ConclusionsS-Ferritin levels are comparable in OSA patients and controls and do not change consistently with obesity level or PAP treatment in our sample.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Ferritin
- OSA
- Inflammation
- ISAC
- BOLD
Publication and Content Type
- ref (subject category)
- art (subject category)
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