L773:1528 1132
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04384naa a2200481 4500 | |
| 001 | oai:DiVA.org:umu-107631 | |
| 003 | SwePub | |
| 008 | 150825s1999 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1076312 URI |
| 040 | a (SwePub)umu | |
| 041 | a engb engb -1 | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Haapala, Jussiu Department of Surgery, Kuopio University Hospital, Kuopio, Finland; Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland4 aut |
| 245 | 1 0 | a Remobilization does not fully restore immobilization induced articular cartilage atrophy. |
| 264 | 1 | b Lippincott Williams & Wilkins,c 1999 |
| 338 | a print2 rdacarrier | |
| 520 | a The recovery of articular cartilage from immobilization induced atrophy was studied. The right hind limbs of 29-week-old beagle dogs were immobilized for 11 weeks and then remobilized for 50 weeks. Cartilage from the immobilized knee was compared with tissue from age matched control animals. After the immobilization period, uncalcified articular cartilage glycosaminoglycan concentration was reduced by 20% to 23%, the reduction being largest (44%) in the superficial zone. The collagen fibril network showed no significant changes, but the amount of collagen crosslinks was reduced (13.5%) during immobilization. After remobilization, glycosaminoglycan concentration was restored at most sites, except for in the upper parts of uncalcified cartilage in the medial femoral and tibial condyles (9% to 17% less glycosaminoglycans than in controls). The incorporation of 35SO4 was not changed, and remobilization also did not alter the birefringence of collagen fibrils. Remobilization restored the proportion of collagen crosslinks to the control level. The changes induced by joint unloading were reversible at most sites investigated, but full restoration of articular cartilage glycosaminoglycan concentration was not obtained in all sites, even after remobilization for 50 weeks. This suggests that lengthy immobilization of a joint can cause long lasting articular cartilage proteoglycan alterations at the same time as collagen organization remains largely unchanged. Because proteoglycans exert strong influence on the biomechanical properties of cartilage, lengthy immobilization may jeopardize the well being of articular cartilage. | |
| 520 | a | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 653 | a Articular cartilage | |
| 653 | a dog | |
| 653 | a immobilzation | |
| 653 | a remobilization | |
| 653 | a proteoglycans | |
| 653 | a biokemi | |
| 653 | a Biochemistry | |
| 653 | a ortopedi | |
| 653 | a Orthopaedics | |
| 700 | 1 | a Arokoski, Jariu Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland4 aut |
| 700 | 1 | a Hyttinen, Mikau Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut |
| 700 | 1 | a Lammi, Mikko,d 1961-u Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group4 aut0 (Swepub:umu)mila0077 |
| 700 | 1 | a Tammi, Markkuu Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut |
| 700 | 1 | a Kovanen, Vuokkou Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland4 aut |
| 700 | 1 | a Helminen, Heikkiu Department of Anatomy, University of Kuopio, Kuopio, Finland4 aut |
| 700 | 1 | a Kiviranta, Ilkkau Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland4 aut |
| 710 | 2 | a Department of Surgery, Kuopio University Hospital, Kuopio, Finland; Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finlandb Department of Rehabilitation Clinic, Kuopio University Hospital, Kuopio, Finland4 org |
| 773 | 0 | t Clinical Orthopaedics and Related Researchd : Lippincott Williams & Wilkinsg :362, s. 218-229q :362<218-229x 0009-921Xx 1528-1132 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107631 |
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