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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004441naa a2200505 4500
001oai:lup.lub.lu.se:1c57f93a-c6c2-4d69-a555-b6fb2bcf7d00
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/16576622 URI
0247 a https://doi.org/10.1186/1471-2261-10-282 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Schlegel, Todd T.4 aut
2451 0a Accuracy of advanced versus strictly conventional 12-lead ECG for detection and screening of coronary artery disease, left ventricular hypertrophy and left ventricular systolic dysfunction
264 c 2010-06-16
264 1b Springer Science and Business Media LLC,c 2010
520 a Background: Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (LVSD). We hypothesized that a similar to 5-min resting 12-lead advanced ECG test ("A-ECG") that combined results from both the advanced and conventional ECG could more accurately screen for these conditions than strictly conventional ECG. Methods: Results from nearly every conventional and advanced resting ECG parameter known from the literature to have diagnostic or predictive value were first retrospectively evaluated in 418 healthy controls and 290 patients with imaging-proven CAD, LVH and/or LVSD. Each ECG parameter was examined for potential inclusion within multi-parameter A-ECG scores derived from multivariate regression models that were designed to optimally screen for disease in general or LVSD in particular. The performance of the best retrospectively-validated A-ECG scores was then compared against that of optimized pooled criteria from the strictly conventional ECG in a test set of 315 additional individuals. Results: Compared to optimized pooled criteria from the strictly conventional ECG, a 7-parameter A-ECG score validated in the training set increased the sensitivity of resting ECG for identifying disease in the test set from 78% (72-84%) to 92% (88-96%) (P < 0.0001) while also increasing specificity from 85% (77-91%) to 94% (88-98%) (P < 0.05). In diseased patients, another 5-parameter A-ECG score increased the PPV of ECG for LVSD from 53% (41-65%) to 92% (78-98%) (P < 0.0001) without compromising related negative predictive value. Conclusion: Resting 12-lead A-ECG scoring is more accurate than strictly conventional ECG in screening for CAD, LVH and LVSD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Kulecz, Walter B.4 aut
7001 a Feiveson, Alan H.4 aut
7001 a Greco, E. Carl4 aut
7001 a DePalma, Jude L.4 aut
7001 a Starc, Vito4 aut
7001 a Vrtovec, Bojan4 aut
7001 a Rahman, M. Atiar4 aut
7001 a Bungo, Michael W.4 aut
7001 a Hayat, Matthew J.4 aut
7001 a Bauch, Terry4 aut
7001 a Delgado, Reynolds4 aut
7001 a Warren, Stafford G.4 aut
7001 a Nunez-Medina, Tulio4 aut
7001 a Medina, Ruben4 aut
7001 a Jugo, Diego4 aut
7001 a Arheden, Håkanu Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)klfy-har
7001 a Pahlm, Olleu Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)klfy-opa
7102 a Klinisk fysiologi, Lundb Sektion V4 org
7730 t BMC Cardiovascular Disordersd : Springer Science and Business Media LLCg 10q 10x 1471-2261
8564 u http://dx.doi.org/10.1186/1471-2261-10-28x freey FULLTEXT
8564 u https://bmccardiovascdisord.biomedcentral.com/track/pdf/10.1186/1471-2261-10-28
8564 8u https://lup.lub.lu.se/record/1657662
8564 8u https://doi.org/10.1186/1471-2261-10-28

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