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  • Feng, QiUniv Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China. (author)

Null association between serum 25-hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non-allergic rhinitis : A Mendelian randomization study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-09-28
  • John Wiley & Sons,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-439118
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439118URI
  • https://doi.org/10.1111/cea.13739DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144731278URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background Previous observational studies have not found a conclusive association between serum 25-hydroxyvitamin D (25(OH)D) levels and allergic rhinitis (AR) or allergic sensitization (AS). Objective To investigate a causal association between 25(OH)D levels with risk of AR and AS, using a two-sample Mendelian randomization (MR) approach. Methods Seven single nucleotide polymorphisms (SNPs), previously shown to be associated with serum 25(OH)D levels, were identified as instrumental variables. The primary outcome was AR, and the secondary outcomes were AS and non-allergic rhinitis (NAR). The genome-wide association (GWA) summary statistics of the outcomes were obtained from two cohort studies (EAGLE Consortium and UK Biobank). An MR analysis with random-effects inverse-variance weighted method was performed as the primary analysis to estimate overall effect size (odds ratio [OR] and 95% confidence interval [CI]). Sensitivity analysis using weighted median method and MR-Egger regression method was conducted. A subgroup analysis based on 25(OH)D synthesis-related SNPs was further applied. Results Serum 25(OH)D levels were not causally associated with risk of AR (OR: 0.960; 95% CI: 0.779-1.184), AS (OR: 1.059; 95% CI: 0.686 to 1.634) or NAR (OR: 0.937; 95% CI: 0.588-1.491). Subgroup analysis also showed null association between 25(OH)D synthesis-related SNPs and the outcomes. Sensitivity analyses yielded similar results. Conclusions and Clinical Relevance This MR study found no evidence supporting a causal association between serum 25(OH)D levels and risk of AR, AS and NAR in European-ancestry population. This argues against the previous postulation that vitamin D supplementation is effective in prevention of allergic diseases.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Bonnelykke, KlausUniv Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark. (author)
  • Ek, Weronica EUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)werek336 (author)
  • Chawes, Bo L.Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark. (author)
  • Yuan, ShuaiKarolinska Institutet (author)
  • Cheung, Ching LungUniv Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, LKS Fac Med, Ctr Genom Sci, Pokfulam, Hong Kong, Peoples R China. (author)
  • Li, Gloria H. Y.Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China. (author)
  • Leung, Raymond Y. H.Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Dept Pharmacol & Pharm,Pokfulam, Hong Kong, Peoples R China. (author)
  • Cheung, Bernard M. Y.Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong, Peoples R China.;Univ Hong Kong, Inst Cardiovasc Sci & Med, Pokfulam, Hong Kong, Peoples R China. (author)
  • Univ Hong Kong, Queen Mary Hosp, LKS Fac Med, Div Clin Pharmacol & Therapeut,Dept Med,Pokfulam, Hong Kong, Peoples R China.Univ Copenhagen, COPSAC, Copenhagen Prospect Studies Asthma Childhood, Herlev & Gentofte Hosp, Copenhagen, Denmark. (creator_code:org_t)

Related titles

  • In:Clinical and Experimental Allergy: John Wiley & Sons51:1, s. 78-860954-78941365-2222

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