WFRF:(Gustafson Bo)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03610naa a2200469 4500 | |
| 001 | oai:DiVA.org:uu-149561 | |
| 003 | SwePub | |
| 008 | 110321s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1495612 URI |
| 024 | 7 | a https://doi.org/10.1097/TP.0b013e31820ae4592 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gustafson, Elisabet K.u Uppsala universitet,Barnkirurgi4 aut0 (Swepub:uu)elgus172 |
| 245 | 1 0 | a The Instant Blood-Mediated Inflammatory Reaction Characterized in Hepatocyte Transplantation |
| 264 | 1 | c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Background. Hepatocyte transplantation (HcTx) has proven to be a safe procedure, although the functional results have been unsatisfactory, probably due to insufficient engraftment or a loss of transplanted mass or function. In this study, we investigate whether hepatocytes in contact with blood induce an inflammatory reaction leading to, similar to what happens in clinical islet transplantation, an instant blood-mediated inflammatory reaction (IBMIR) resulting in an early loss of transplanted cells. Methods. By using an experimental model that mimics the portal vein blood flow, we could study different parameters reflecting the effects on the innate immunity elicited by hepatocytes in contact with ABO-matched human blood. Results. We report that all aspects of the IBMIR such as platelet and granulocyte consumption, coagulation, and complement activation were demonstrated. Addition of various specific inhibitors of coagulation allowed us to clearly delineate the various stages of the hepatocyte-triggered IBMIR and show that the reaction was triggered by tissue factor. Analysis of a case of clinical HcTx showed that hepatocyte-induced IBMIR also occurs in vivo. Both the inflammatory and the coagulation aspects were controlled by low-molecular-weight dextran sulfate. Conclusion. Isolated hepatocytes in contact with blood induce the IBMIR in vitro, and there are indications that these events are also relevant in vivo. According to these findings, HcTx would benefit from controlling a wider range of signals from the innate immune system. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a IBMIR | |
| 653 | a Islet transplantation | |
| 653 | a Cell transplantation | |
| 653 | a Innate immunity | |
| 653 | a Engraftment | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Elgue, Gracielau Uppsala universitet,Klinisk immunologi4 aut |
| 700 | 1 | a Hughes, Robin D.4 aut |
| 700 | 1 | a Mitry, Ragai R.4 aut |
| 700 | 1 | a Sanchez, Javieru Uppsala universitet,Klinisk immunologi4 aut |
| 700 | 1 | a Haglund, Ulfu Uppsala universitet,Gastrointestinalkirurgi4 aut0 (Swepub:uu)ulfhagnd |
| 700 | 1 | a Meurling, Staffanu Uppsala universitet,Barnkirurgi4 aut0 (Swepub:uu)stafmeur |
| 700 | 1 | a Dhawan, Anil4 aut |
| 700 | 1 | a Korsgren, Olleu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)ollekors |
| 700 | 1 | a Nilsson, Bou Uppsala universitet,Klinisk immunologi,Forskargrupp Bo Nilsson4 aut0 (Swepub:uu)bonils |
| 710 | 2 | a Uppsala universitetb Barnkirurgi4 org |
| 773 | 0 | t Transplantationg 91:6, s. 632-638q 91:6<632-638x 0041-1337x 1534-6080 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-149561 |
| 856 | 4 8 | u https://doi.org/10.1097/TP.0b013e31820ae459 |
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