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ASXLs binding to th...
ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
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- Zhang, Yi (författare)
- Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA.;Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA.
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- Xie, Guojia (författare)
- Natl Inst Diabet & Digest & Kidney Dis, Lab Endocrinol & Receptor Biol, NIH, Bethesda, MD 20892 USA.
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- Lee, Ji-Eun (författare)
- Natl Inst Diabet & Digest & Kidney Dis, Lab Endocrinol & Receptor Biol, NIH, Bethesda, MD 20892 USA.
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- Zandian, Mohamad (författare)
- Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA.
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- Sudarshan, Deepthi (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Estavoyer, Benjamin (författare)
- Maisonneuve Rosemont Hosp Res Ctr, Montreal, PQ H1T 2M4, Canada.
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- Benz, Caroline (författare)
- Uppsala universitet,Biokemi
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- Viita, Tiina (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Asgaritarghi, Golareh (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Lachance, Catherine (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Messmer, Clemence (författare)
- Maisonneuve Rosemont Hosp Res Ctr, Montreal, PQ H1T 2M4, Canada.
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- Simonetti, Leandro (författare)
- Uppsala universitet,Biokemi
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- Sinha, Vikrant Kumar (författare)
- Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA.
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- Lambert, Jean-Philippe (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Chen, Yu-Wen (författare)
- Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan.
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- Wang, Shu-Ping (författare)
- Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan.
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- Ivarsson, Ylva (författare)
- Uppsala universitet,Biokemi
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- Affar, El Bachir (författare)
- Maisonneuve Rosemont Hosp Res Ctr, Montreal, PQ H1T 2M4, Canada.;Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada.
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- Cote, Jacques (författare)
- Laval Univ, CHU Quebec Univ Laval Res, Oncol Div, St Patrick Res Grp Basic Oncol,Canc Res Ctr, Quebec City, PQ G1R 3S3, Canada.
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- Ge, Kai (författare)
- Natl Inst Diabet & Digest & Kidney Dis, Lab Endocrinol & Receptor Biol, NIH, Bethesda, MD 20892 USA.
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- Kutateladze, Tatiana G. (författare)
- Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA.
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Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA;Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA. Natl Inst Diabet & Digest & Kidney Dis, Lab Endocrinol & Receptor Biol, NIH, Bethesda, MD 20892 USA. (creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers. Here, we report a novel function of the PHD2 and PHD3 (PHD2/3) fingers of MLL4 and MLL3 that bind to ASXL2, a component of the Polycomb repressive H2AK119 deubiquitinase (PR-DUB) complex. The structure of MLL4 PHD2/3 in complex with the MLL-binding helix (MBH) of ASXL2 and mutational analyses reveal the molecular mechanism which is conserved in homologous ASXL1 and ASXL3. The native interaction of the Trithorax MLL3/4 complexes with the PR-DUB complex in vivo depends solely on MBH of ASXL1/2, coupling the two histone modifying activities. ChIP-seq analysis in embryonic stem cells demonstrates that MBH of ASXL1/2 is required for the deubiquitinase BAP1 recruitment to MLL4-bound active enhancers. Our findings suggest an ASXL1/2-dependent functional link between the MLL3/4 and PR-DUB complexes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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- Av författaren/redakt...
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Zhang, Yi
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Xie, Guojia
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Lee, Ji-Eun
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Zandian, Mohamad
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Sudarshan, Deept ...
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Estavoyer, Benja ...
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visa fler...
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Benz, Caroline
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Viita, Tiina
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Asgaritarghi, Go ...
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Lachance, Cather ...
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Messmer, Clemenc ...
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Simonetti, Leand ...
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Sinha, Vikrant K ...
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Lambert, Jean-Ph ...
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Chen, Yu-Wen
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Wang, Shu-Ping
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Ivarsson, Ylva
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Affar, El Bachir
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Cote, Jacques
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Ge, Kai
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Kutateladze, Tat ...
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Uppsala universitet