WFRF:(Hultman Christina)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03755naa a2200349 4500 | |
| 001 | oai:DiVA.org:liu-41251 | |
| 003 | SwePub | |
| 008 | 091010s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-412512 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1365-2249.2007.03474.x2 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ekerfelt, Christina,d 1957-u Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)chrek55 |
| 245 | 1 0 | a Mercury exposure as a model for deviation of cytokine responses in experimental Lyme arthritis :b HgCl2 treatment decreases T helper cell type 1-like responses and arthritis severity but delays eradication of Borrelia burgdorferi in C3H/HeN mice |
| 264 | c 2007-08-02 | |
| 264 | 1 | b Oxford University Press (OUP),c 2007 |
| 338 | a print2 rdacarrier | |
| 520 | a Lyme borreliosis is a complex infection, where some individuals develop so-called ‘chronic borreliosis’. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borrelia and for avoiding development of chronic disease. Many studies aimed at altering the Th1/Th2 balance in Lyme arthritis employed mice deficient in cytokine genes, but the outcome has not been clear-cut, due possibly to the high redundancy of cytokines. This study aimed at studying the importance of the Th1/Th2 balance in murine Borrelia arthritis by using the Th2-deviating effect of subtoxic doses of inorganic mercury. Ninety-eight C3H/HeN mice were divided into four groups: Borrelia-infected (Bb), Borrelia-infected exposed to HgCl2 (BbHg), controls exposed to HgCl2 alone and normal controls. Mice were killed on days 3, 16, 44 and 65 post-Borrelia inoculation. Arthritis severity was evaluated by histology, spirochaetal load determined by Borrelia culture, IgG2a- and IgE-levels analysed by enzyme-linked immunosorbemt assay (ELISA) and cytokine-secreting cells detected by enzyme-linked immunospot (ELISPOT). BbHg mice showed less severe histological arthritis, but delayed eradication of spirochaetes compared to Bb mice, associated with increased levels of IgE (Th2-induced) and decreased levels of IgG2a (Th1-induced), consistent with a Th2-deviation. Both the numbers of Th1 and Th2 cytokine-secreting cells were reduced in BbHg mice, possibly explained by the fact that numbers of cytokine-secreting cells do not correlate with cytokine concentration. In conclusion, this study supports the hypothesis that a Th1-like response is required for optimal eradication of Borrelia. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Andersson, M.u Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut |
| 700 | 1 | a Olausson, Anna,d 1981-u Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)annol01 |
| 700 | 1 | a Bergström, S.u Department of Microbiology, University of Umeå, Umeå, Sweden4 aut |
| 700 | 1 | a Hultman, Per,d 1957-u Linköpings universitet,Institutionen för molekylär och klinisk medicin,Hälsouniversitetet4 aut0 (Swepub:liu)perhu66 |
| 710 | 2 | a Linköpings universitetb Klinisk immunologi4 org |
| 773 | 0 | t Clinical and Experimental Immunologyd : Oxford University Press (OUP)g 150:1, s. 189-197q 150:1<189-197x 0009-9104x 1365-2249 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2249.2007.03474.x |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-41251 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1365-2249.2007.03474.x |
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