WFRF:(James D.)
Sökning: WFRF:(James D.) > (2005-2009) > Genetic association...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04523naa a2200877 4500 | |
| 001 | oai:DiVA.org:uu-122923 | |
| 003 | SwePub | |
| 008 | 100421s2009 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:119087330 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1229232 URI |
| 024 | 7 | a https://doi.org/10.1038/gene.2009.192 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1190873302 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Lu, R4 aut |
| 245 | 1 0 | a Genetic associations of LYN with systemic lupus erythematosus |
| 264 | c 2009-04-16 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case-control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived population, consisting of 2463 independent cases and 3131 unrelated controls, shows significant association with rs6983130 in a female-only analysis with 2254 cases and 2228 controls (P=1.1 x 10(-4), odds ratio (OR)=0.81 (95% confidence interval: 0.73-0.90)). This single nucleotide polymorphism (SNP) is located in the 5' untranslated region within the first intron near the transcription initiation site of LYN. In addition, SNPs upstream of the first exon also show weak and sporadic association in subsets of the total European-American population. Multivariate logistic regression analysis implicates rs6983130 as a protective factor for systemic lupus erythematosus (SLE) susceptibility when anti-dsDNA, anti-chromatin, anti-52 kDa Ro or anti-Sm autoantibody status were used as covariates. Subset analysis of the European-American female cases by American College of Rheumatology classification criteria shows a reduction in the risk of hematological disorder with rs6983130 compared with cases without hematological disorders (P=1.5 x 10(-3), OR=0.75 (95% CI: 0.62-0.89)). None of the 90 SNPs tested show significant association with SLE in the African American or Korean populations. These results support an association of LYN with European-derived individuals with SLE, especially within autoantibody or clinical subsets. | |
| 653 | a systemic lupus erythematosus | |
| 653 | a association | |
| 653 | a LYN | |
| 653 | a SNP | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Vidal, G S4 aut |
| 700 | 1 | a Kelly, J A4 aut |
| 700 | 1 | a Delgado-Vega, Angelica Mu Uppsala universitet,Institutionen för genetik och patologi4 aut |
| 700 | 1 | a Howard, X K4 aut |
| 700 | 1 | a Macwana, S R4 aut |
| 700 | 1 | a Dominguez, N4 aut |
| 700 | 1 | a Klein, W4 aut |
| 700 | 1 | a Burrell, C4 aut |
| 700 | 1 | a Harley, I T4 aut |
| 700 | 1 | a Kaufman, K M4 aut |
| 700 | 1 | a Bruner, G R4 aut |
| 700 | 1 | a Moser, K L4 aut |
| 700 | 1 | a Gaffney, P M4 aut |
| 700 | 1 | a Gilkeson, G S4 aut |
| 700 | 1 | a Wakeland, E K4 aut |
| 700 | 1 | a Li, Q-Z4 aut |
| 700 | 1 | a Langefeld, C D4 aut |
| 700 | 1 | a Marion, M C4 aut |
| 700 | 1 | a Divers, J4 aut |
| 700 | 1 | a Alarcón, G S4 aut |
| 700 | 1 | a Brown, E E4 aut |
| 700 | 1 | a Kimberly, R P4 aut |
| 700 | 1 | a Edberg, J C4 aut |
| 700 | 1 | a Ramsey-Goldman, R4 aut |
| 700 | 1 | a Reveille, J D4 aut |
| 700 | 1 | a McGwin, G4 aut |
| 700 | 1 | a Vilá, L M4 aut |
| 700 | 1 | a Petri, M A4 aut |
| 700 | 1 | a Bae, S-C4 aut |
| 700 | 1 | a Cho, S-K4 aut |
| 700 | 1 | a Bang, S-Y4 aut |
| 700 | 1 | a Kim, I4 aut |
| 700 | 1 | a Choi, C-B4 aut |
| 700 | 1 | a Martin, J4 aut |
| 700 | 1 | a Vyse, T J4 aut |
| 700 | 1 | a Merrill, J T4 aut |
| 700 | 1 | a Harley, J B4 aut |
| 700 | 1 | a Alarcón-Riquelme, Marta Eu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala |
| 700 | 1 | a Nath, S K4 aut |
| 700 | 1 | a James, J A4 aut |
| 700 | 1 | a Guthridge, J M4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för genetik och patologi4 org |
| 773 | 0 | t Genes and Immunityd : Springer Science and Business Media LLCg 10:5, s. 397-403q 10:5<397-403x 1466-4879x 1476-5470 |
| 856 | 4 | u https://www.nature.com/articles/gene200919.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122923 |
| 856 | 4 8 | u https://doi.org/10.1038/gene.2009.19 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:119087330 |
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