Sökning: WFRF:(Larsson Tobias E.) > Identification of c...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06446naa a2200649 4500 | |
001 | oai:gup.ub.gu.se/254149 | |
003 | SwePub | |
008 | 240528s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-134737 | |
024 | 7 | a https://gup.ub.gu.se/publication/2541492 URI |
024 | 7 | a https://doi.org/10.1016/j.parkreldis.2017.01.0162 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1347372 URI |
040 | a (SwePub)gud (SwePub)umu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Magdalinou, N. K.4 aut |
245 | 1 0 | a Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics |
264 | 1 | b Elsevier BV,c 2017 |
520 | a Introduction: Neurodegenerative parkinsonian syndromes have significant clinical and pathological overlap, making early diagnosis difficult. Cerebrospinal fluid (CSF) biomarkers may aid the differentiation of these disorders, but other than a-synuclein and neurofilament light chain protein, which have limited diagnostic power, specific protein biomarkers remain elusive. Objectives: To study disease mechanisms and identify possible CSF diagnostic biomarkers through discovery proteomics, which discriminate parkinsonian syndromes from healthy controls. Methods: CSF was collected consecutively from 134 participants; Parkinson's disease (n = 26), atypical parkinsonian syndromes (n = 78, including progressive supranuclear palsy (n = 36), multiple system atrophy (n = 28), corticobasal syndrome (n = 14)), and elderly healthy controls (n = 30). Participants were divided into a discovery and a validation set for analysis. The samples were subjected to tryptic digestion, followed by liquid chromatography-mass spectrometry analysis for identification and relative quantification by isobaric labelling. Candidate protein biomarkers were identified based on the relative abundances of the identified tryptic peptides. Their predictive performance was evaluated by analysis of the validation set. Results: 79 tryptic peptides, derived from 26 proteins were found to differ significantly between atypical parkinsonism patients and controls. They included acute phase/inflammatory markers and neuronal/synaptic markers, which were respectively increased or decreased in atypical parkinsonism, while their levels in PD subjects were intermediate between controls and atypical parkinsonism. Conclusion: Using an unbiased proteomic approach, proteins were identified that were able to differentiate atypical parkinsonian syndrome patients from healthy controls. Our study indicates that markers that may reflect neuronal function and/or plasticity, such as the amyloid precursor protein, and inflammatory markers may hold future promise as candidate biomarkers in parkinsonism. (C) 2017 Published by Elsevier Ltd. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng |
653 | a Parkinsonian disorders | |
653 | a Parkinson's disease | |
653 | a Progressive supranuclear palsy | |
653 | a Multiple system atrophy | |
653 | a PROGRESSIVE SUPRANUCLEAR PALSY | |
653 | a MULTIPLE SYSTEM ATROPHY | |
653 | a DISEASE | |
653 | a GENE | |
653 | a DISCOVERY | |
653 | a ALZHEIMER | |
653 | a DIAGNOSIS | |
653 | a CRITERIA | |
700 | 1 | a Noyce, A. J.4 aut |
700 | 1 | a Pinto, Ruiu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)rupi0002 |
700 | 1 | a Lindström, E.u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut |
700 | 1 | a Holmén Larsson, Jessica,d 1971u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xhojes |
700 | 1 | a Hölttä, Mikkou Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xholtm |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Morris, H. R.4 aut |
700 | 1 | a Skillbäck, Tobiasu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xskito |
700 | 1 | a Warner, T. T.4 aut |
700 | 1 | a Lees, A. J.4 aut |
700 | 1 | a Pike, I.4 aut |
700 | 1 | a Ward, M.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Gobom, Johanu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xgobjo |
710 | 2 | a Umeå universitetb Kemiska institutionen4 org |
773 | 0 | t Parkinsonism & Related Disordersd : Elsevier BVg 37, s. 65-71q 37<65-71x 1353-8020x 1873-5126 |
856 | 4 | u https://discovery.ucl.ac.uk/1543442/1/Magdalinou_Identification_candidate_cerebrospinal.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/254149 |
856 | 4 8 | u https://doi.org/10.1016/j.parkreldis.2017.01.016 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-134737 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.