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  • Carlzon, DanielGothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research (författare)

Both Low and High Serum Insulin-like Growth Factor-I Levels Associate with Increased Risk of Cardiovascular Events in Elderly Men.

  • Artikel/kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • The Endocrine Society,2014

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/201001
  • https://gup.ub.gu.se/publication/201001URI
  • https://doi.org/10.1210/jc.2014-1575DOI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Aims: Most previous prospective studies suggest that low serum insulin-like growth factor-I (IGF-I) associates with increased risk of cardiovascular disease (CVD) events while other studies suggest that high serum IGF-I associates with increased risk of CVD events. We tested the hypothesis that not only low, but also high, serum IGF-I associate with increased risk of CVD events in elderly men. Methods and Results: Serum IGF-I levels were measured in 2901 elderly men (aged 69 to 81 years) included in the prospective population-based MrOS-Sweden cohort. Data for CVD events were obtained from national Swedish registers with no loss of follow-up. During follow-up (median 5.1 yrs) 589 of the participants experienced a CVD event. The association between serum IGF-I and risk of CVD events was nonlinear, and restricted cubic spline Cox regression analysis revealed a U-shaped association between serum IGF-I levels and CVD events (p<0.01 for nonlinearity). Low as well as high serum IGF-I (quintile 1 or 5 vs. quintiles 2-4) significantly associated with increased risk for CVD events (hazard ratio (HR) = 1.25, 95% confidence interval (CI) 1.02-1.54; and HR = 1.35, 95% CI 1.10-1.66, respectively). These associations remained after adjustment for prevalent CVD and multiple risk factors. High serum IGF-I associated with increased risk of coronary heart disease (CHD) events but not with risk of cerebrovascular events. Conclusion: Both low and high serum IGF-I levels are risk markers for CVD events in elderly men. The association between high serum IGF-I and CVD events is mainly driven by CHD events.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Svensson, Johan,1964Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research(Swepub:gu)xsjohc (författare)
  • Petzold, Max,1973Gothenburg University,Göteborgs universitet,Akademistatistik,Centre for Applied Biostatistics(Swepub:gu)xpemax (författare)
  • Karlsson, Magnus K (författare)
  • Ljunggren, Osten (författare)
  • Tivesten, Åsa,1969Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xtivas (författare)
  • Mellström, Dan,1945Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xmelda (författare)
  • Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xohlcl (författare)
  • Göteborgs universitetCentre for Bone and Arthritis Research (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Journal of clinical endocrinology and metabolism: The Endocrine Society99:111945-71970021-972X

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