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  • Beale, M.Wellcome Sanger Institute, Cambridge, UK (författare)

CONTEMPORARY SYPHILIS IS CHARACTERISED BY RAPID GLOBAL SPREAD OF PANDEMIC TREPONEMA PALLIDUM LINEAGES

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-07-06
  • BMJ Publishing Group Ltd,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-95231
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95231URI
  • https://doi.org/10.1136/sextrans-2021-sti.55DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Syphilis is an important sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The last two decades have seen syphilis incidence rise in many high-income countries, yet the evolutionary and epidemiological relationships that underpin this are poorly understood, as is the global T. pallidum population structure.Methods: We assembled a geographically and temporally diverse collection of clinical and laboratory samples, performing direct sequencing on the majority, and combining these with 133 publicly available sequences to compile a dataset comprising 726 T. pallidum genomes. We analysed the resulting genomes using detailed phylogenetic analysis and clustering.Results: We show that syphilis globally can be described by only two deeply branching lineages, Nichols and SS14. We show that both of these lineages can be found circulatingcon currently in 12 of the 23 countries sampled. To provide further phylodynamic resolution we subdivided Treponema pallidum subspecies pallidum into 17 distinct sublineages. Importantly, like SS14, we provide evidence that two Nichols sublineages have expanded clonally across 9 countries contemporaneously with SS14. Moreover, pairwise genome analysis showed that recent isolates circulating in 14 different countries were genetically identical in their core genome to those from other countries, suggesting frequent exchange through international transmission pathways. This contrasts with the majority of samples collected prior to 1983, which are phylogenetically distinct from these more recently isolated sublineages. Bayesian temporal analysis provided evidence of a population bottleneck and decline occurring during the late 1990s, followed by a rapid population expansion a decade later. This was driven by the dominant T. pallidum sublineages circulating today, many of which are resistant to macrolides.Conclusion: Combined we show that the population of contemporary syphilis in high-income countries has undergone a recent and rapid global expansion. This dataset will provide a framework for future characterisation and epidemiological investigation of syphilis populations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Marks, M.London School of Hygiene and Tropical Medicine, London, UK (författare)
  • Cole, M.National Infection Service, Public Health England, London, UK (författare)
  • Lee, M.British Columbia Centre for Disease Control, Vancouver, Canada (författare)
  • Pitt, R.National Infection Service, Public Health England, London, UK (författare)
  • Ruis, C.University of Cambridge Department of Medicine, Cambridge, UK (författare)
  • Naidu, P.Alberta Precision Laboratories, Edmonton, Canada (författare)
  • Unemo, Magnus,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for STI(Swepub:oru)muo (författare)
  • Krajden, M.British Columbia Centre for Disease Control, Vancouver, Canada (författare)
  • Lukehart, S.University of Washington, Seattle, USA (författare)
  • Morshed, M.British Columbia Centre for Disease Control, Vancouver, Canada (författare)
  • Fifer, H.National Infection Service, Public Health England, London, UK (författare)
  • Thomson, N.Wellcome Sanger Institute, Cambridge, UK; London School of Hygiene and Tropical Medicine, London, UK (författare)
  • Wellcome Sanger Institute, Cambridge, UKLondon School of Hygiene and Tropical Medicine, London, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Sexually Transmitted Infections: BMJ Publishing Group Ltd97:Suppl. 1, s. A17-A171368-49731472-3263

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