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Sökning: WFRF:(Papadopoulos K. I.) > Proposal of 0.5 mg ...

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FältnamnIndikatorerMetadata
00016535naa a2201621 4500
001oai:gup.ub.gu.se/310443
003SwePub
008240528s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-486012
009oai:prod.swepub.kib.ki.se:148166584
024a https://gup.ub.gu.se/publication/3104432 URI
024a https://doi.org/10.1111/all.151672 DOI
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4860122 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1481665842 URI
040 a (SwePub)gud (SwePub)uud (SwePub)ki
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Zuberbier, T.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
2451 0a Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food-A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA(2)LEN position paper
264 c 2021-11-24
264 1b Wiley,c 2022
520 a Background Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as "may contain traces of" is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy, and sesame seeds. Conclusion Based on the literature studied for this review, it can be stated that cross-contamination of the 14 major food allergens below 0.5 mg/100 g is likely not to endanger most food allergic patients when a standard portion of food is consumed. We propose to use the statement "this product contains the named allergens in the list of ingredients, it may contain traces of other contaminations (to be named, e.g. nut) at concentrations less than 0.5 mg per 100 g of this product" for a voluntary declaration on processed food packages. This level of avoidance of cross-contaminations can be achieved technically for most processed foods, and the statement would be a clear and helpful message to the consumers. However, it is clearly acknowledged that a voluntary declaration is only a first step to a legally binding solution. For this, further research on threshold levels is encouraged.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a anaphylaxis
653 a food allergy
653 a nutrition
653 a exercise-induced anaphylaxis
653 a cows milk
653 a oral immunotherapy
653 a peanut
653 a allergy
653 a challenge
653 a children
653 a diagnosis
653 a adolescents
653 a sesame
653 a tests
653 a Allergy
653 a Immunology
653 a anaphylaxis
700a Dorr, T.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
700a Aberer, W.u Med Univ Graz, Dept Dermatol, Graz, Austria4 aut
700a Alvaro, M.u Hosp St Joan de Deu, Serv Allergol Immunol Clin, Barcelona, Spain4 aut
700a Angier, E.u Univ Southampton, Fac Med, Primary Care Populat Sci & Med Educ, Southampton, Hants, England4 aut
700a Arasi, S.u Bambino Gesu Hosp IRCCS, Pediat Allergol Unit, Rome, Italy4 aut
700a Arshad, H.u Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.;Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England.;St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport, Wight, England4 aut
700a Ballmer-Weber, B.u Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland.;Kantonsspital St Gallen, Clin Dermatol & Allergol, St Gallen, Switzerland4 aut
700a Bartra, J.u Hosp Clin Barcelona, Serv Neumol & Allergia Resp, Unitat Allergia, Barcelona, Spain.;Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain4 aut
700a Beck, L.u Univ Rochester, Dept Dermatol, Med Ctr, New York, NY USA4 aut
700a Begin, P.u CHU St Justine, Montreal, PQ, Canada4 aut
700a Janson, Christeru Uppsala universitet,Lung- allergi- och sömnforskning,Klinisk fysiologi4 aut0 (Swepub:uu)chrisjn
700a Bislimovska, J.u Ss Cyril & Methodius Univ Skopje, Fac Med, WHO Collaborating Ctr, Inst Occupat Hlth RNM, Skopje, North Macedonia4 aut
700a Bousquet, J.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany.;Univ Hosp Montpellier, Montpellier, France.;MACVIA France, Montpellier, France4 aut
700a Brockow, K.u Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany4 aut
700a Bush, A.u Imperial Coll, London, England.;Royal Brompton Hosp, London, England4 aut
700a Cianferoni, A.u Univ Penn, Dept Pediat, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA4 aut
700a Cork, M. J.u Univ Sheffield, Sheffield, S Yorkshire, England,European Acad Allergy & Clin Immunol, Zurich, Switzerland,Helsinki Univ Hosp, Skin & Allergy Hosp, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland,Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Dermatol & Venereol 2, Allergy Unit, Athens, Greece,Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany,Ss Cyril & Methodius Univ Skopje, Fac Med, WHO Collaborating Ctr, Inst Occupat Hlth RNM, Skopje, North Macedonia,Univ Barcelona, Hosp Clin, ENT Dept, Rhinol Unit,CIBERES, Barcelona, Catalonia, Spain.;Univ Barcelona, CIBERES, IDIBAPS, Smell Clin,ENT Dept,Hosp Clin, Barcelona, Catalonia, Spain4 aut
700a Custovic, A.u Imperial Coll London, Natl Heart & Lung Inst, London, England4 aut
700a Darsow, U.u Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany4 aut
700a Jong, N.u Erasmus MC, Sect Allergol & Clin Immunol, Dept Internal Med, Rotterdam, Netherlands4 aut
700a Deleanu, D.u Univ Med & Pharm Iuliu Hatieganu, Allergy, IRGH, Cluj Napoca, Romania4 aut
700a Del Giacco, S.u Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy,Ss Cyril & Methodius Univ Skopje, Fac Med, WHO Collaborating Ctr, Inst Occupat Hlth RNM, Skopje, North Macedonia4 aut
700a Deschildre, A.u Univ Lille, CHU Lille, Lille, France.;Hop Jeanne de Flandre, Pediat Pulmonol & Allergy Unit, Lille, France4 aut
700a Galvin, A. D.u Univ Coll Cork, Cork, Ireland.;Sechenov Univ Moscow, Moscow, Russia.;Anaphylaxis Ireland, Cork, Ireland4 aut
700a Ebisawa, M.u Natl Hosp Org Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan4 aut
700a Fernandez-Rivas, M.u Univ Complutense UCM, Hosp Clin San Carlos, Fac Med, Allergy Dept,IdISSC, Madrid, Spain4 aut
700a Ferrer, M.u Clin Univ Navarra, Dept Allergy, Pamplona, Spain4 aut
700a Fiocchi, A.u Bambino Gesu Hosp IRCCS, Pediat Allergol Unit, Rome, Italy4 aut
700a van Wijk, R. G.u Erasmus MC, Sect Allergol & Clin Immunol, Dept Internal Med, Rotterdam, Netherlands,Univ Bologna, Dept Med & Surg Sci, Pediat Unit, Bologna, Italy,Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands4 aut
700a Gotua, M.u Ctr Allergy & Immunol, Tbilisi, Georgia4 aut
700a Grimshaw, K.u Salford Royal Fdn Trust, Dietet Dept, Salford Care Org, Salford, Lancs, England4 aut
700a Grunhagen, J.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
700a Heffler, E.u IRCCS Humanitas Res Hosp, Personalized Med Asthma & Allergy, Rozzano, MI, Italy.;Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy4 aut
700a Hide, M.u Hiroshima Citizens Hosp, Dept Dermatol, Hiroshima, Japan4 aut
700a Hoffmann-Sommergruber, K.u Med Univ Vienna, Dept Pathophysiol & Allergy Res, Vienna, Austria4 aut
700a Incorvaia, C.u ASST Pini CTO, Cardiac Pulm Rehabil, Milan, Italy4 aut
700a Janson, C.4 aut
700a John, S. M.u Univ Osnabrueck, Dept Dermatol Environm Med Hlth Theory, Osnabruck, Germany.;Univ Osnabrueck, Inst Interdisciplinary Dermatol Prevent & Rehabil, Osnabruck, Germany4 aut
700a Jones, C.4 aut
700a Jutel, M.4 aut
700a Katoh, N.u Kyoto Prefectural Univ Med, Dept Dermatol, Kyoto, Japan4 aut
700a Kendziora, B.u Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergy, Univ Hosp, Munich, Germany4 aut
700a Kinaciyan, T.u Med Univ Vienna, Dept Dermatol, Vienna, Austria4 aut
700a Knol, E.u Univ Med Ctr Utrecht, Dept Dermatol & Allergol, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Lab Translat Immunol, Utrecht, Netherlands4 aut
700a Kurbacheva, O.u NRC Inst Immunol FMBA, Moscow, Russia4 aut
700a Lau, S.u Charite Univ Med Berlin, Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany4 aut
700a Loh, R.u Univ Western Australia, Perth Childrens Hosp, Dept Immunol, Perth, WA, Australia4 aut
700a Lombardi, C.u Ente Osped Fdn Poliambulanza, Unita Dipartimentale Allergol Immunol Clin & Mala, Brescia, Italy4 aut
700a Makela, M.u Asthma & Allergy Assoc, Stockholm, Sweden4 aut
700a Marchisotto, M. J.u MJM Advisory, New York, NY USA.;Univ Michigan Med, Mary H Weiser Food Allergy Ctr, Ann Arbor, MI USA4 aut
700a Makris, M.4 aut
700a Maurer, M.4 aut
700a Meyer, R.u Imperial Coll, Dept Paediat, London, England4 aut
700a Mijakoski, D.u Ss Cyril & Methodius Univ Skopje, Fac Med, WHO Collaborating Ctr, Inst Occupat Hlth RNM, Skopje, North Macedonia4 aut
700a Minov, J.4 aut
700a Mullol, J.4 aut
700a Nilsson, C.u Karolinska Institutet4 aut
700a Nowak-Wegrzyn, A.u Icahn Sch Med Mt Sinai, Div Allergy & Immunol, Dept Pediat, Jaffe Food Allergy Inst,Kravis Childrens Hosp, New York, NY 10029 USA4 aut
700a Nwaru, Bright I,d 1978u Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Krefting Res Ctr, Inst Med, Gothenburg, Sweden4 aut0 (Swepub:gu)xnwabr
700a Odemyr, M.4 aut
700a Pajno, G. B.u Univ Messina, Pediat Unit, Policlin Hospitsl, Messina, Italy4 aut
700a Paudel, S.u Civil Serv Hosp, Kathmandu, Nepal4 aut
700a Papadopoulos, N. G.u Univ Athens, Allergy Dept, Pediat Clin 2, Athens, Greece4 aut
700a Renz, H.u Philipps Univ Marburg, Inst Lab Med & Pathobiochem, Univ Hosp Giessen & Marburg, Mol Diagnost, Marburg, Germany.;Sechenov Univ, Dept Clin Immunol & Allergol, Lab Immunopathol, Moscow, Russia4 aut
700a Ricci, G.4 aut
700a Ring, J.u Tech Univ Munich, Sch Med, Dept Dermatol & Allergy Biederstein, Munich, Germany.;Christine K Hne Ctr Allergy Res & Educ CK Care, Davos, Switzerland4 aut
700a Rogala, B.u Univ Silesia, Dept Internal Dis Allergol & Clin Immunol Med, Katowice, Poland4 aut
700a Sampson, H.u Elliot & Roslyn Jaffe Food Allergy Inst, New York, NY USA.;Kravis Childrens Hosp, Div Allergy & Immunol, New York, NY USA.;Icahn Sch Med Mt Sinai, Dept Pediat, New York, NY 10029 USA4 aut
700a Senna, G.u Verona Univ & Gen Hosp, Asthma Ctr & Allergy Unit, Verona, Italy4 aut
700a Sitkauskiene, B.u Lithuanian Univ Hlth Sci, Dept Immunol & Allergol, Kaunas, Lithuania4 aut
700a Smith, P. K.u Griffith Univ, Southport, Qld, Australia4 aut
700a Stevanovic, K.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
700a Stoleski, S.4 aut
700a Szajewska, H.u Med Univ Warsaw, Dept Paediat, Warsaw, Poland4 aut
700a Tanaka, A.u Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Dermatol, Hiroshima, Japan4 aut
700a Todo-Bom, A.u Ctr Hosp & Univ Coimbra, Allergy & Clin Immunol Unit, Coimbra, Portugal4 aut
700a Topal, F. A.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
700a Valovirta, E.u Univ Turku, Dept Lung Dis & Clin Allergol, Turku, Finland.;Terveystalo Turku, Allergy Clin, Turku, Finland4 aut
700a Van Ree, R.4 aut
700a Venter, C.u Univ Colorado Denver, Sch Med, Aurora, CO USA.;Childrens Hosp Colorado, Aurora, CO USA4 aut
700a Wohrl, S.u Floridsdorf Allergy Ctr FAZ, Vienna, Austria4 aut
700a Wong, G. W. K.u Chinese Univ Hong Kong, Dept Paediat, Hong Kong, Peoples R China4 aut
700a Zhao, Z. T.u Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China4 aut
700a Worm, M.u Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germany4 aut
710a Charite Univ Med Berlin, Dept Dermatol & Allergy, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth, Comprehens Allergy Ctr, Berlin, Germanyb Med Univ Graz, Dept Dermatol, Graz, Austria4 org
773t Allergyd : Wileyg 77:6, s. 1736-1750q 77:6<1736-1750x 0105-4538x 1398-9995
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.15167
856u https://doi.org/10.1111/all.15167y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1702283/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://gup.ub.gu.se/publication/310443
8564 8u https://doi.org/10.1111/all.15167
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486012
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148166584

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