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Rituximab versus cy...
Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis: 2-year results of a randomised trial
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- Jones, Rachel B. (författare)
- Addenbrookes Hospital, England
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- Furuta, Shunsuke (författare)
- Addenbrookes Hospital, England
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- Cohen Tervaert, Jan Willem (författare)
- Maastricht University, Netherlands
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- Hauser, Thomas (författare)
- IZZ Immunol Zentrum, Switzerland
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- Luqmani, Raashid (författare)
- Nuffield Orthopaed Centre, England
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- Morgan, Matthew D. (författare)
- University of Birmingham, England
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- Au Peh, Chen (författare)
- Royal Adelaide Hospital, Australia; University of Adelaide, Australia
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- Savage, Caroline O. (författare)
- University of Birmingham, England
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- Segelmark, Mårten (författare)
- Lund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Tesar, Vladimir (författare)
- Charles University of Prague, Czech Republic
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- van Paassen, Pieter (författare)
- Maastricht University, Netherlands
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- Walsh, Michael (författare)
- McMaster University, Canada; McMaster University, Canada
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- Westman, Kerstin (författare)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University Hospital Skåne, Sweden; Lund University, Sweden
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- Jayne, David R. W. (författare)
- Addenbrookes Hospital, England
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(creator_code:org_t)
- 2015-03-04
- 2015
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 74:6, s. 1178-1182
- Relaterad länk:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objectives The RITUXVAS trial reported similar remission induction rates and safety between rituximab and cyclophosphamide based regimens for antineutrophil cytoplasm antibody (ANCA)-associated vasculitis at 12months; however, immunosuppression maintenance requirements and longer-term outcomes after rituximab in ANCA-associated renal vasculitis are unknown. Methods Forty-four patients with newly diagnosed ANCA-associated vasculitis and renal involvement were randomised, 3:1, to glucocorticoids plus either rituximab (375mg/m(2)/weekx4) with two intravenous cyclophosphamide pulses (n=33, rituximab group), or intravenous cyclophosphamide for 3-6months followed by azathioprine (n=11, control group). Results The primary end point at 24months was a composite of death, end-stage renal disease and relapse, which occurred in 14/33 in the rituximab group (42%) and 4/11 in the control group (36%) (p=1.00). After remission induction treatment all patients in the rituximab group achieved complete B cell depletion and during subsequent follow-up, 23/33 (70%) had B cell return. Relapses occurred in seven in the rituximab group (21%) and two in the control group (18%) (p=1.00). All relapses in the rituximab group occurred after B cell return. Conclusions At 24months, rates of the composite outcome of death, end-stage renal disease and relapse did not differ between groups. In the rituximab group, B cell return was associated with relapse. Trial registration number ISRCTN28528813.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- B cells; Cyclophosphamide; Granulomatosis with polyangiitis; Systemic vasculitis; Treatment
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Jones, Rachel B.
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Furuta, Shunsuke
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Cohen Tervaert, ...
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Hauser, Thomas
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Luqmani, Raashid
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Morgan, Matthew ...
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Au Peh, Chen
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Savage, Caroline ...
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Segelmark, Mårte ...
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Tesar, Vladimir
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van Paassen, Pie ...
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Walsh, Michael
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Westman, Kerstin
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Jayne, David R. ...
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