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- Rask-Andersen, MathiasUppsala universitet,Funktionell farmakologi (author)
Advances in kinase targeting : current clinical use and clinical trials
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- Elsevier BV,2014
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-97591
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97591URI
- https://doi.org/10.1016/j.tips.2014.09.007DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-238746URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- Phosphotransferases, also known as kinases, are the most intensively studied protein drug target category in current pharmacological research, as evidenced by the vast number of kinase-targeting agents enrolled in active clinical trials. This development has emerged following the great success of small-molecule, orally available protein kinase inhibitors for the treatment of cancer, starting with the introduction of imatinib (Gleevec (R)) in 2003. The pharmacological utility of kinase-targeting has expanded to include treatment of inflammatory diseases, and rapid development is ongoing for kinase-targeted therapies in a broad array of indications in ophthalmology, analgesia, central nervous system (CNS) disorders, and the complications of diabetes, osteoporosis, and otology. In this review we highlight specifically the kinase drug targets and kinase-targeting agents being explored in current clinical trials. This analysis is based on a recent estimate of all established and clinical trial drug mechanisms of action, utilizing private and public databases to create an extensive dataset detailing aspects of more than 3000 approved and experimental drugs.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Läkemedelskemi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medicinal Chemistry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- clinical trials
- phosphotransferase
- drug targets
- protein kinase
- serine/threonine-protein kinase
- rosine-protein kinase
Added entries (persons, corporate bodies, meetings, titles ...)
- Zhang, JinUppsala universitet,Umeå universitet,Kemiska institutionen,Funktionell farmakologi(Swepub:uu)jinzh961 (author)
- Fabbro, Doriano (author)
- Schiöth, Helgi BUppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi (author)
- Uppsala universitetFunktionell farmakologi (creator_code:org_t)
Related titles
- In:TIPS - Trends in Pharmacological Sciences: Elsevier BV35:11, s. 60-760165-61471873-3735
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