Sökning: L773:1872 7506 OR L773:0925 4927 >
Inhibitory and exci...
Inhibitory and excitatory neurotransmitter systems in depressed and healthy : A positron emission tomography and magnetic resonance spectroscopy study
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- Persson, Jonas, 1983- (författare)
- Uppsala universitet,Cervenka: Psykiatri
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- Wall, Anders (författare)
- Uppsala universitet,Radiologi,Uppsala Univ Hosp, PET Ctr, Uppsala, Sweden.
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- Weis, Jan, 1956- (författare)
- Uppsala universitet,Radiologi
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- Gingnell, Malin, 1982- (författare)
- Uppsala universitet,Cervenka: Psykiatri,Institutionen för psykologi
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- Antoni, Gunnar (författare)
- Uppsala universitet,Preparativ läkemedelskemi,Uppsala Univ Hosp, PET Ctr, Uppsala, Sweden.
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- Lubberink, Mark (författare)
- Uppsala universitet,Radiologi
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- Bodén, Robert, 1973- (författare)
- Uppsala universitet,Cervenka: Psykiatri
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Psychiatry Research. - : Elsevier. - 0925-4927 .- 1872-7506. ; 315
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The Gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems are implicated in depression. While previous studies found reduced GABA levels, and a tendency towards reduced Glu, using proton (H-1) magnetic resonance spectroscopy (H-1-MRS), little is known about GABA(A) receptor availability in depression. Here, the aim was to characterize GABA and Glu-levels in dorsal anterior cingulate cortex (dACC), whole-brain GABA(A) availability, and their relationship in patients with depression compared to healthy controls. Forty-two patients and 45 controls underwent H-1-MRS using a MEGA-PRESS sequence to quantify dACC GABA+ and Glu (contrasted against creatine [Cr]). Immediately preceding the H-1-MRS, a subsample of 28 patients and 15 controls underwent positron emission tomography (PET) with [C-11]Flumazenil to assess whole-brain GABA(A) receptor availability. There were no differences in dACC GABA+/Cr or Glu/Cr ratios between patients and controls. The same was true for whole-brain GABA(A) receptor availability. However, there was a significant negative relationship between GABA+/Cr ratio and receptor availability in ACC, in a whole-brain voxel-wise analysis across patients and controls, controlling for group or depressive symptoms. This relatively large study did not support the GABA-deficit hypothesis in depression, but shed light on GABA-system functioning, suggesting a balance between neurotransmitter concentration and receptor availability in dACC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- GABA
- Glutamate
- PET
- Magnetic resonance spectroscopy
- Depression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Persson, Jonas, ...
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Wall, Anders
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Weis, Jan, 1956-
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Gingnell, Malin, ...
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Antoni, Gunnar
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Lubberink, Mark
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visa fler...
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Bodén, Robert, 1 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Psychiatry Resea ...
- Av lärosätet
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Uppsala universitet