Internet-Based Cognitive Behavioral Therapy for Depression: A Systematic Review and Individual Patient Data Network Meta-analysis

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Fältnamn	Indikatorer	Metadata
000		12524naa a2201453 4500
001		oai:DiVA.org:lnu-111650
003		SwePub
008		220429s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:145623858
009		oai:gup.ub.gu.se/304532
009		oai:DiVA.org:su-193532
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-1116502 URI
024	7	a https://doi.org/10.1001/jamapsychiatry.2020.43642 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456238582 URI
024	7	a https://gup.ub.gu.se/publication/3045322 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1935322 URI
040		a (SwePub)lnud (SwePub)kid (SwePub)gud (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Karyotaki, Eiriniu University of Bern, Switzerland;Vrije Universiteit Amsterdam, Netherlands;Harvard Medical School, USA4 aut
245	1 0	a Internet-Based Cognitive Behavioral Therapy for Depression :b A Systematic Review and Individual Patient Data Network Meta-analysis
264	1	b American Medical Association,c 2021
338		a print2 rdacarrier
500		a Carlbring and Johansson are part of the Individual Patient Data Meta-Analyses for Depression (IPDMA-DE) Collaboration, which is included as co-author of the article.
520		a IMPORTANCE: Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them.OBJECTIVE: To provide personalized estimates of short-term and long-term relative efficacy of guided and unguided iCBT for depression using patient-level information.DATA SOURCES: We searched PubMed, Embase, PsycInfo, and Cochrane Library to identify randomized clinical trials (RCTs) published up to January 1, 2019.STUDY SELECTION: Eligible RCTs were those comparing guided or unguided iCBT against each other or against any control intervention in individuals with depression. Available individual patient data (IPD) was collected from all eligible studies. Depression symptom severity was assessed after treatment, 6 months, and 12 months after randomization.DATA EXTRACTION AND SYNTHESIS: We conducted a systematic review and IPD network meta-analysis and estimated relative treatment effect sizes across different patient characteristics through IPD network meta-regression.MAIN OUTCOMES AND MEASURES: Patient Health Questionnaire-9 (PHQ-9) scores.RESULTS: Of 42 eligible RCTs, 39 studies comprising 9751 participants with depression contributed IPD to the IPD network meta-analysis, of which 8107 IPD were synthesized. Overall, both guided and unguided iCBT were associated with more effectiveness as measured by PHQ-9 scores than control treatments over the short term and the long term. Guided iCBT was associated with more effectiveness than unguided iCBT (mean difference [MD] in posttreatment PHQ-9 scores, -0.8; 95% CI, -1.4 to -0.2), but we found no evidence of a difference at 6 or 12 months following randomization. Baseline depression was found to be the most important modifier of the relative association for efficacy of guided vs unguided iCBT. Differences between unguided and guided iCBT in people with baseline symptoms of subthreshold depression (PHQ-9 scores 5-9) were small, while guided iCBT was associated with overall better outcomes in patients with baseline PHQ-9 greater than 9.CONCLUSIONS AND RELEVANCE: In this network meta-analysis with IPD, guided iCBT was associated with more effectiveness than unguided iCBT for individuals with depression, benefits were more substantial in individuals with moderate to severe depression. Unguided iCBT was associated with similar effectiveness among individuals with symptoms of mild/subthreshold depression. Personalized treatment selection is entirely possible and necessary to ensure the best allocation of treatment resources for depression.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a SAMHÄLLSVETENSKAPx Psykologix Tillämpad psykologi0 (SwePub)501022 hsv//swe
650	7	a SOCIAL SCIENCESx Psychologyx Applied Psychology0 (SwePub)501022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Allmänmedicin0 (SwePub)302242 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex General Practice0 (SwePub)302242 hsv//eng
650	7	a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650	7	a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
653		a Cognitive Behavioral Therapy
653		a Depression Therapy
653		a Depressive Disorder Therapy
653		a Humans
653		a Internet-Based Intervention
653		a Network Meta-Analysis
653		a Psychology
653		a Psykologi
653		a Psychology
700	1	a Efthimiou, Orestisu University of Bern, Switzerland;University of Oxford, UK4 aut
700	1	a Miguel, Clarau Vrije Universiteit Amsterdam, Netherlands;Amsterdam Public Health Research Institute, Netherlands4 aut
700	1	a Bermpohl, Frederic Maas Genanntu University of Wuppertal, Germany4 aut
700	1	a Furukawa, Toshi Au University of Wuppertal, Germany;Kyoto University Graduate School of Medicine/School of Public Health, Japan4 aut
700	1	a Cuijpers, Pimu Vrije Universiteit Amsterdam, Netherlands;Amsterdam Public Health Research Institute, Netherlands4 aut
700	1	a Riper, Heleenu Vrije Universiteit Amsterdam, Netherlands;Amsterdam Public Health Research Institute, Netherlands;GGZ inGeest, Netherlands4 aut
700	1	a Patel, Vikramu Harvard Medical School, Sweden4 aut
700	1	a Mira, Adrianau MINECO, Spain;Valencia University, Spain4 aut
700	1	a Gemmil, Alan W.u Heidelberg Repatriation Hospital, Australia4 aut
700	1	a Yeung, Albert S.u Harvard University, USA4 aut
700	1	a Lange, Alfredu University of Amsterdam, Netherlands4 aut
700	1	a Williams, Alishia D.u University of New South Wales, Australia4 aut
700	1	a Mackinnon, Andrewu University of New South Wales, Australia; University of Melbourne, Australia4 aut
700	1	a Geraedts, Annau HumanTotalCare, Netherlands4 aut
700	1	a van Straten, Annemiekeu Vrije Universiteit Amsterdam, Netherlands;Amsterdam Public Health Research Institute, Netherlands4 aut
700	1	a Meyer, Björnu Gaia AG, Germany;University of London, UK4 aut
700	1	a Björkelund, Cecilia,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xbjoce
700	1	a Knaevelsrud, Christineu Freie Universität Berlin, Germany4 aut
700	1	a Beevers, Christopher G.u The University of Texas at Austin, USA4 aut
700	1	a Botella, Cristinau Jaume I University, Spain;Instituto Salud Carlos III, Spain4 aut
700	1	a Strunk, Daniel R.u The Ohio State University, USA4 aut
700	1	a Mohr, David C.u Northwestern University, USA4 aut
700	1	a Ebert, David D.u Friedrich-Alexander-University Erlangen-Nürnberg, Germany4 aut
700	1	a Kessler, Davidu University of Bristol, UK;National Institute for Health Research Bristol Biomedical Research Centre, UK4 aut
700	1	a Richards, Dereku Trinity College Dublin School of Psychology, Ireland;SilverCloud Health, Ireland4 aut
700	1	a Littlewood, Elizabethu University of York, UK4 aut
700	1	a Forsell, Eriku Karolinska Institutet, Sweden;Region Stockholm, Sweden4 aut
700	1	a Feng, Fanu Massachusetts General Hospital, USA4 aut
700	1	a Wang, Fangu China Academy of Chinese Medical Sciences, China4 aut
700	1	a Andersson, Gerhardu Karolinska Institutet, Sweden;Region Stockholm, Sweden;Linköping University, Sweden4 aut
700	1	a Hadjistavropoulos, Heatheru University of Regina, Canada4 aut
700	1	a Christensen, Heleenu University of New South Wales, Australia4 aut
700	1	a Ezawa, Iony D.u The Ohio State University, USA4 aut
700	1	a Choi, Isabellau University of Sydney, Australia4 aut
700	1	a Rosso, Isabelle Mu McLean Hospital, USA;Harvard Medical School, USA4 aut
700	1	a Klein, Jan Philippu Lübeck University, Germany4 aut
700	1	a Shumake, Jasonu The University of Texas at Austin, USA4 aut
700	1	a Garcia-Campayo, Javieru Miguel Servet University Hospital, Spain;RedIAPP, Spain4 aut
700	1	a Milgrom, Jeannetteu Heidelberg Repatriation Hospital, Australia4 aut
700	1	a Smith, Jessicau Imperial College London, UK4 aut
700	1	a Montero-Marin, Jesusu University of Oxford, UK4 aut
700	1	a Newby, Jill M.u University of New South Wales, Australia4 aut
700	1	a Bretón-López, Juanau Jaume I University, Spain;Instituto Salud Carlos III, Spain4 aut
700	1	a Schneider, Justineu University of Nottingham, UK4 aut
700	1	a Vernmark, Kristoferu Linköping University, Sweden;Psykologpartners, Sweden4 aut
700	1	a Bücker, Larau University Medical Center Hamburg-Eppendorf, Germany4 aut
700	1	a Sheeber, Lisa B.u Oregon Research Institute, USA4 aut
700	1	a Warmerdam, Lisanneu National Health Care Institute, Netherlands4 aut
700	1	a Farrer, Louiseu The Australian National University, Australia4 aut
700	1	a Heinrich, Manuelu Freie Universität Berlin, Germany4 aut
700	1	a Huibers, Marcus J. H.u Vrije Universiteit Amsterdam, Netherlands;Amsterdam Public Health Research Institute, Netherlands4 aut
700	1	a Kivi, Marieu Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology4 aut0 (Swepub:gu)xkivma
700	1	a Kraepelien, Martinu Karolinska Institutet, Sweden;Region Stockholm, Sweden4 aut
700	1	a Forand, Nicholas R.u The Ohio State University Wexner Medical Center, USA;The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, USA4 aut
700	1	a Pugh, Nickyu University of Regina, Canada4 aut
700	1	a Lindefors, Nilsu Karolinska Institutet, Sweden;Region Stockholm, Sweden4 aut
700	1	a Lintvedt, Oveu Norwegian Center for E-health research, Norway4 aut
700	1	a Zagorscak, Pavleu Freie Universität Berlin, Germany4 aut
700	1	a Carlbring, Peru Stockholms universitet,Klinisk psykologi4 aut0 (Swepub:su)pecar
700	1	a Phillips, Rachelu Imperial College London School of Public Health, UK4 aut
700	1	a Johansson, Robertu Stockholms universitet,Klinisk psykologi4 aut0 (Swepub:su)rojo4696
700	1	a Kessler, Ronald C.u Harvard Medical School, USA4 aut
700	1	a Brabyn, Sallyu SilverCloud Health, Ireland4 aut
700	1	a Perini, Sarahu The Clinical Psychology Centre, Australia4 aut
700	1	a Rauch, Scott L.u McLean Hospital, USA4 aut
700	1	a Gilbody, Simonu University of York, UK;Hull York Medical School, UK4 aut
700	1	a Moritz, Steffenu University Medical Center Hamburg-Eppendorf, Germany4 aut
700	1	a Berger, Thomasu University of Bern, Switzerland4 aut
700	1	a Pop, Victoru Tilburg University, Netherlands4 aut
700	1	a Kaldo, Viktor,c Professoru Linnéuniversitetet,Institutionen för psykologi (PSY),Karolinska Institutet, Sweden4 aut0 (Swepub:lnu)vikaaa
700	1	a Spek, Violau Tilburg University, Netherlands4 aut
700	1	a Forsell, Yvonneu Karolinska Institutet, Sweden;Region Stockholm, Sweden4 aut
710	2	a University of Bern, Switzerland;Vrije Universiteit Amsterdam, Netherlands;Harvard Medical School, USAb University of Bern, Switzerland;University of Oxford, UK4 org
773	0	t JAMA psychiatryd : American Medical Associationg 78:4, s. 361-371q 78:4<361-371x 2168-6238x 2168-622X
856	4	u https://boris.unibe.ch/151988/1/Karyotaki_JAMAPsychiatry_2021_epub.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-111650
856	4 8	u https://doi.org/10.1001/jamapsychiatry.2020.4364
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145623858
856	4 8	u https://gup.ub.gu.se/publication/304532
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193532

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Av författaren/redakt...: Karyotaki, Eirin ...; Efthimiou, Orest ...; Miguel, Clara; Bermpohl, Freder ...; Furukawa, Toshi ...; Cuijpers, Pim; visa fler...; Riper, Heleen; Patel, Vikram; Mira, Adriana; Gemmil, Alan W.; Yeung, Albert S.; Lange, Alfred; Williams, Alishi ...; Mackinnon, Andre ...; Geraedts, Anna; van Straten, Ann ...; Meyer, Björn; Björkelund, Ceci ...; Knaevelsrud, Chr ...; Beevers, Christo ...; Botella, Cristin ...; Strunk, Daniel R ...; Mohr, David C.; Ebert, David D.; Kessler, David; Richards, Derek; Littlewood, Eliz ...; Forsell, Erik; Feng, Fan; Wang, Fang; Andersson, Gerha ...; Hadjistavropoulo ...; Christensen, Hel ...; Ezawa, Iony D.; Choi, Isabella; Rosso, Isabelle ...; Klein, Jan Phili ...; Shumake, Jason; Garcia-Campayo, ...; Milgrom, Jeannet ...; Smith, Jessica; Montero-Marin, J ...; Newby, Jill M.; Bretón-López, Ju ...; Schneider, Justi ...; Vernmark, Kristo ...; Bücker, Lara; Sheeber, Lisa B.; Warmerdam, Lisan ...; Farrer, Louise; Heinrich, Manuel; Huibers, Marcus ...; Kivi, Marie; Kraepelien, Mart ...; Forand, Nicholas ...; Pugh, Nicky; Lindefors, Nils; Lintvedt, Ove; Zagorscak, Pavle; Carlbring, Per; Phillips, Rachel; Johansson, Rober ...; Kessler, Ronald ...; Brabyn, Sally; Perini, Sarah; Rauch, Scott L.; Gilbody, Simon; Moritz, Steffen; Berger, Thomas; Pop, Victor; Kaldo, Viktor, P ...; Spek, Viola; Forsell, Yvonne; visa färre...

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