WFRF:(Ben Menachem Elinor 1945)
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Seizure aggravation-evidence that oxcarbazepine requires monitoring.
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- Ben-Menachem, Elinor, 1945 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
- (creator_code:org_t)
- 2008-06-28
- 2008
- Engelska.
- Ingår i: Epilepsy currents / American Epilepsy Society. - : SAGE Publications. - 1535-7597. ; 8:4, s. 93-5
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- AGGRAVATION OF SEIZURES AND/OR EEG FEATURES IN CHILDREN TREATED WITH OXCARBAZEPINE MONOTHERAPY: Vendrame M, Khurana DS, Cruz M, Melvin J, Valencia I, Legido A, Kothare SV Epilepsia20074811:2116-212017645535 Epub 2007 Jul 21. PURPOSE: Exacerbation of epilepsy may occur following initiation of therapy with antiepileptic drugs (AEDs). The aim of this study is to analyze the clinical and EEG characteristics of a group of pediatric patients with worsening of seizures and/or EEG deterioration while on oxcarbazepine (OXC). METHODS: A retrospective analysis of a clinical database was performed to identify patients with epilepsy treated with OXC over the past 3 years. History, neurological examination, and EEG findings were reviewed to identify any who had developed exacerbation of seizures or new abnormalities on EEG. RESULTS: Of 290 patients on OXC, we identified 12 patients with new onset seizures, all with initial normal neurological exam and normal EEG, who developed either worsening of preexisting seizures, new seizure types, and/or EEG deterioration following introduction of OXC monotherapy. EEG changes were primarily characterized by new onset of generalized epileptiform activity not reported on the initial baseline EEG. Following substitution of OXC with a broad spectrum AED, significant improvement of seizure control and improvement in the EEG was observed. CONCLUSIONS: These findings suggest that OXC can aggravate seizures and/or worsen EEG features in children. Following initiation of therapy with OXC, monitoring of patients with follow-up EEGs may be important, especially in patients who do not show adequate response to therapy.
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