Sökning: WFRF:(De Simone Sara) > Identification of a...
Fältnamn | Indikatorer | Metadata |
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000 | 08479naa a2201885 4500 | |
001 | oai:DiVA.org:umu-119064 | |
003 | SwePub | |
008 | 160411s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133166150 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1190642 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddv4922 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1331661502 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Figueroa, Jonine D.4 aut |
245 | 1 0 | a Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry |
264 | c 2016-01-04 | |
264 | 1 | b Oxford University Press,c 2016 |
338 | a print2 rdacarrier | |
520 | a Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10−6), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10−11) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10−10). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region—the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r2 = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case–case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Middlebrooks, Candace D.4 aut |
700 | 1 | a Banday, A. Rouf4 aut |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Garcia-Closas, Montserrat4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a Koutros, Stella4 aut |
700 | 1 | a Kiemeney, Lambertus A.4 aut |
700 | 1 | a Rafnar, Thorunn4 aut |
700 | 1 | a Bishop, Timothy4 aut |
700 | 1 | a Furberg, Helena4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Golka, Klaus4 aut |
700 | 1 | a Gago-Dominguez, Manuela4 aut |
700 | 1 | a Taylor, Jack A.4 aut |
700 | 1 | a Fletcher, Tony4 aut |
700 | 1 | a Siddiq, Afshan4 aut |
700 | 1 | a Cortessis, Victoria K.4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Cussenot, Olivier4 aut |
700 | 1 | a Benhamou, Simone4 aut |
700 | 1 | a Prescott, Jennifer4 aut |
700 | 1 | a Porru, Stefano4 aut |
700 | 1 | a Dinney, Colin P.4 aut |
700 | 1 | a Malats, Nuria4 aut |
700 | 1 | a Baris, Dalsu4 aut |
700 | 1 | a Purdue, Mark P.4 aut |
700 | 1 | a Jacobs, Eric J.4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Chung, Charles C.4 aut |
700 | 1 | a Vermeulen, Sita H.4 aut |
700 | 1 | a Aben, Katja K.4 aut |
700 | 1 | a Galesloot, Tessel E.4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Sulem, Patrick4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Kiltie, Anne E.4 aut |
700 | 1 | a Harland, Mark4 aut |
700 | 1 | a Teo, Mark4 aut |
700 | 1 | a Offit, Kenneth4 aut |
700 | 1 | a Vijai, Joseph4 aut |
700 | 1 | a Bajorin, Dean4 aut |
700 | 1 | a Kopp, Ryan4 aut |
700 | 1 | a Fiorito, Giovanni4 aut |
700 | 1 | a Guarrera, Simonetta4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Selinski, Silvia4 aut |
700 | 1 | a Hengstler, Jan G.4 aut |
700 | 1 | a Gerullis, Holger4 aut |
700 | 1 | a Ovsiannikov, Daniel4 aut |
700 | 1 | a Blaszkewicz, Meinolf4 aut |
700 | 1 | a Esteban Castelao, Jose4 aut |
700 | 1 | a Calaza, Manuel4 aut |
700 | 1 | a Martinez, Maria Elena4 aut |
700 | 1 | a Cordeiro, Patricia4 aut |
700 | 1 | a Xu, Zongli4 aut |
700 | 1 | a Panduri, Vijayalakshmi4 aut |
700 | 1 | a Kumar, Rajiv4 aut |
700 | 1 | a Gurzau, Eugene4 aut |
700 | 1 | a Koppova, Kvetoslava4 aut |
700 | 1 | a Bueno-De-Mesquita, H. Bas4 aut |
700 | 1 | a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi,Njurcancer4 aut0 (Swepub:umu)bolj0001 |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Conti, David4 aut |
700 | 1 | a Stern, Marianna C.4 aut |
700 | 1 | a Pike, Malcolm C.4 aut |
700 | 1 | a Van den Berg, David4 aut |
700 | 1 | a Yuan, Jian-Min4 aut |
700 | 1 | a Hohensee, Chancellor4 aut |
700 | 1 | a Jeppson, Rebecca P.4 aut |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Roupret, Morgan4 aut |
700 | 1 | a Comperat, Eva4 aut |
700 | 1 | a Turman, Constance4 aut |
700 | 1 | a De Vivo, Immaculata4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Lindstrom, Sara4 aut |
700 | 1 | a Carta, Angela4 aut |
700 | 1 | a Pavanello, Sofia4 aut |
700 | 1 | a Arici, Cecilia4 aut |
700 | 1 | a Mastrangelo, Giuseppe4 aut |
700 | 1 | a Kamat, Ashish M.4 aut |
700 | 1 | a Zhang, Liren4 aut |
700 | 1 | a Gong, Yilei4 aut |
700 | 1 | a Pu, Xia4 aut |
700 | 1 | a Hutchinson, Amy4 aut |
700 | 1 | a Burdett, Laurie4 aut |
700 | 1 | a Wheeler, William A.4 aut |
700 | 1 | a Karagas, Margaret R.4 aut |
700 | 1 | a Johnson, Alison4 aut |
700 | 1 | a Schned, Alan4 aut |
700 | 1 | a Hosain, G. M. Monawar4 aut |
700 | 1 | a Schwenn, Molly4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Tardon, Adonina4 aut |
700 | 1 | a Serra, Consol4 aut |
700 | 1 | a Carrato, Alfredo4 aut |
700 | 1 | a Garcia-Closas, Reina4 aut |
700 | 1 | a Lloreta, Josep4 aut |
700 | 1 | a Andriole, Gerald, Jr.4 aut |
700 | 1 | a Grubb, Robert, III4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Weinstein, Stephanie4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Haiman, Christopher A.4 aut |
700 | 1 | a Landi, Maria Teresa4 aut |
700 | 1 | a Caporaso, Neil E.4 aut |
700 | 1 | a Fraumeni, Joseph F., Jr.4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Silverman, Debra T.4 aut |
700 | 1 | a Prokunina-Olsson, Ludmila4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Gong, Yl4 aut |
710 | 2 | a Umeå universitetb Urologi och andrologi4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Pressg 25:6, s. 1203-1214q 25:6<1203-1214x 0964-6906x 1460-2083 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/25/6/1203/18527151/ddv492.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119064 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddv492 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133166150 |
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