Bileopancreatic Diversion with Duodenal Switch lowers both Early and Late Phases of Glucose, Insulin and Proinsulin responses after Meal

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Fältnamn	Indikatorer	Metadata
000		03958naa a2200397 4500
001		oai:DiVA.org:uu-111314
003		SwePub
008		091209s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1113142 URI
024	7	a https://doi.org/10.1007/s11695-010-0102-62 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Johansson, Hans-Erik,d 1960-u Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)hanjo402
245	1 0	a Bileopancreatic Diversion with Duodenal Switch lowers both Early and Late Phases of Glucose, Insulin and Proinsulin responses after Meal
264		c 2010-03-03
264	1	b Springer Science and Business Media LLC,c 2010
338		a print2 rdacarrier
520		a Hyperproinsulinemia is associated with obesity and type 2 diabetes. We explored the after-meal dynamics of proinsulin and insulin and postprandial effects on glucose and lipids in patients treated with bileopancreatic diversion with duodenal switch (BPD-DS) surgery compared with normal-weight controls [body mass index (BMI)+/- SD, 23.2 +/- 2.4 kg/m(2)].Ten previously morbidly obese (BMI +/- SD, 53.5 +/- 3.8 kg/m(2)) patients free from diabetes who had undergone BPD-DS (BMI +/- SD, 29.0 +/- 5.2 kg/m(2)) 2 years earlier were recruited. A standardised meal (2400 kJ) was ingested, and glucose, proinsulin, insulin, free fatty acids and triglycerides (TGs) were determined during 180 min. Follow-up characteristics yearly on glucose, lipids, creatinine and uric acid over 3 years after BPD-DS are presented.Fasting glucose and insulin were lower, 0.4 mmol/L and 4.6 pmol/L, respectively, in the BPD-DS group despite higher BMI. Fasting proinsulin was similar in both groups. Postprandial area under the curve (AUC) for glucose, proinsulin and insulin did not differ between the two groups (p = 0.106-734). Postprandial changes in glucose, proinsulin and insulin were essentially similar but absolute concentrations of proinsulin and insulin were lower in the later phases in the BPD-DS group (p = 0.052-0.001). Postprandial AUC for TGs was lower in the BPD-DS group (p = 0.005). Postprandial changes in TGs were lowered in the intermediate phase (p = 0.07-0.08) and in the late phase (0.002). Follow-up data showed markedly lowered creatinine and uric acid after BPD-DS.BPD-DS surgery induces a large weight loss and lowers, close to normal, postprandial responses of glucose, proinsulin and insulin but with marked lowering of TGs.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653		a Proinsulin; Insulin; Obesity; Bileopancreatic diversion with duodenal switch
653		a Endocrinology
653		a Endokrinologi
700	1	a Hänni, Arvou Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)arvohann
700	1	a Karlsson, F. Andersu Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism4 aut0 (Swepub:uu)anderska
700	1	a Edén-Engström, Brittu Uppsala universitet,Institutionen för medicinska vetenskaper,Endokrinologi, diabetes och metabolism4 aut
700	1	a Öhrvall, Margaretau Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)margohrv
700	1	a Sundbom, Magnusu Uppsala universitet,Institutionen för kirurgiska vetenskaper4 aut0 (Swepub:uu)magsundb
700	1	a Zethelius, Björnu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)bjorzeth
710	2	a Uppsala universitetb Geriatrik4 org
773	0	t Obesity Surgeryd : Springer Science and Business Media LLCg 20:5, s. 549-558q 20:5<549-558x 0960-8923x 1708-0428
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-111314
856	4 8	u https://doi.org/10.1007/s11695-010-0102-6

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