Sökning: WFRF:(Gómez Isabel) > Role of PATJ in str...
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000 | 10562naa a2200793 4500 | |
001 | oai:DiVA.org:uu-524644 | |
003 | SwePub | |
008 | 240313s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5246442 URI |
024 | 7 | a https://doi.org/10.1038/s41420-024-01857-z2 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Medina-Dols, Ainau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.4 aut |
245 | 1 0 | a Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis |
264 | 1 | b Springer Nature,c 2024 |
338 | a electronic2 rdacarrier | |
520 | a Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial cells (ECs) in the context of stroke outcome. PATJ expression analyses in patient's blood revealed that: (i) the risk allele of rs76221407 induces higher expression of PATJ, (ii) PATJ is downregulated 24 h after IS, and (iii) its expression is significantly lower in those patients with functional independence, measured at 3 months with the modified Rankin scale ((mRS) <= 2), compared to those patients with marked disability (mRS = 4-5). In mice brains, PATJ was also downregulated in the injured hemisphere at 48 h after ischemia. Oxygen-glucose deprivation and hypoxia-dependent of Hypoxia Inducible Factor-1 alpha also caused PATJ depletion in ECs. To study the effects of PATJ downregulation, we generated PATJ-knockdown human microvascular ECs. Their transcriptomic profile evidenced a complex cell reprogramming involving Notch, TGF-ss, PI3K/Akt, and Hippo signaling that translates in morphological and functional changes compatible with endothelial to mesenchymal transition (EndMT). PATJ depletion caused loss of cell-cell adhesion, upregulation of metalloproteases, actin cytoskeleton remodeling, cytoplasmic accumulation of the signal transducer C-terminal transmembrane Mucin 1 (MUC1-C) and downregulation of Notch and Hippo signaling. The EndMT phenotype of PATJ-depleted cells was associated with the nuclear recruitment of MUC1-C, YAP/TAZ, beta-catenin, and ZEB1. Our results suggest that PATJ downregulation 24 h after IS promotes EndMT, an initial step prior to secondary activation of a pro-angiogenic program. This effect is associated with functional independence suggesting that activation of EndMT shortly after stroke onset is beneficial for stroke recovery. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Canellas, Guillemu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Capo, Toniu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Sole, Montseu Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Mola-Caminal, Marinau Uppsala universitet,Medicinsk epidemiologi,Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut0 (Swepub:uu)marmo445 |
700 | 1 | a Cullell, Nataliau Hosp Univ Mutua Terrassa, Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Terrassa, Spain.;Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Jaume, Marinau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Nadal-Salas, Laurau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Llinas, Jaumeu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Gomez, Lluisu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Tur, Silviau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Hosp Univ Son Espases HUSE, Dept Neurol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Jimenez, Carmenu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Hosp Univ Son Espases HUSE, Dept Neurol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Diaz, Rosa M.u Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Hosp Univ Son Espases HUSE, Dept Neurol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Carrera, Catyu Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.;Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Muino, Elenau Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Gallego-Fabrega, Cristinau Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Soriano-Tarraga, Carolinau Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Ruiz-Guerra, Laurau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Pol-Fuster, Josepu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Asensio, Victoru Dept Genet GEN IB, HUSE, IdISBa, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Muncunill, Josepu Genom & Bioinformat Platform, IdISBa, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Fleischer, Aarneu Genom & Bioinformat Platform, IdISBa, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Iglesias, Amandau Hosp Univ Son Espases IdISBa Palma, Dept Resp Med, Palma De Mallorca, Spain.;Inst Salud Carlos III, CIBERES, Madrid, Spain.;CIBER Resp Dis CIBERES, Madrid, Spain.4 aut |
700 | 1 | a Giralt-Steinhauer, Evau Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Lazcano, Uxueu Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Fernandez-Perez, Isabelu Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Jimenez-Balado, Joanu Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Gabriel-Salazar, Marinau Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Garcia-Gabilondo, Miguelu Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Lei, Tingu Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Torres-Aguila, Nuria-Pazu Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Carcel-Marquez, Jarau Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Llado, Jeroniau Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Olmos, Gabrielu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
700 | 1 | a Rosell, Annau Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Montaner, Joanu Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.;Univ Seville, CSIC, Inst Biomed Sevilla,IBiS, Seville, Spain.;Hosp Univ Virgen Macarena, Dept Neurol, Seville, Spain.4 aut |
700 | 1 | a Planas, Anna M.u CSIC, Inst Invest Biomed Barcelona IIBB, Dept Neurosci & Expt Therapeut, Barcelona, Spain.;Inst Invest Biomed August Pi I Sunyer IDIBAPS, Area Neurosci, Barcelona, Spain.4 aut |
700 | 1 | a Rabionet, Raquelu Univ Barcelona UB, Dept Genet Microbiol & Stat, Barcelona, Spain.;Inst Recerca St Joan de Deu, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid, Spain.4 aut |
700 | 1 | a Hernandez-Guillamon, Maru Univ Autonoma Barcelona, Vall dHebron Res Inst, Neurovasc Res Lab, Barcelona, Spain.4 aut |
700 | 1 | a Jimenez-Conde, Jordiu Hosp del Mar Med Res Inst, Neurol, Barcelona, Spain.4 aut |
700 | 1 | a Fernandez-Cadenas, Israelu Inst Recerca St Pau IR ST PAU, Stroke Pharmacogen & Genet, Barcelona, Spain.4 aut |
700 | 1 | a Vives-Bauza, Cristofolu Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 aut |
710 | 2 | a Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.b Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Neurobiol Lab, Palma De Mallorca, Spain.;Univ Balear Isl UIB, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol, Palma De Mallorca, Spain.4 org |
773 | 0 | t Cell Death Discoveryd : Springer Natureg 10q 10x 2058-7716 |
856 | 4 | u https://doi.org/10.1038/s41420-024-01857-zy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1844137/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524644 |
856 | 4 8 | u https://doi.org/10.1038/s41420-024-01857-z |
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