Suicide among patients with amyotrophic lateral sclerosis

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Fältnamn	Indikatorer	Metadata
000		04153naa a2200517 4500
001		oai:DiVA.org:uu-107841
003		SwePub
008		090831s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:oru-41462
009		oai:prod.swepub.kib.ki.se:117736237
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1078412 URI
024	7	a https://doi.org/10.1093/brain/awn1612 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-414622 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1177362372 URI
040		a (SwePub)uud (SwePub)orud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fang, Fangu Karolinska Institutet4 aut
245	1 0	a Suicide among patients with amyotrophic lateral sclerosis
264		c 2008-07-22
264	1	a Oxford, United Kingdom :b Oxford University Press (OUP),c 2008
338		a print2 rdacarrier
520		a Studies on the suicide risk among patients with amyotrophic lateral sclerosis (ALS) in countries without legalized euthanasia or assisted suicide are important additions to data on the wish to die of these patients. We conducted a population-based cohort study in Sweden between 1965 and 2004, which comprised of 6642 patients with incident ALS identified from the Swedish Inpatient Register. We calculated the standardized mortality ratios (SMRs) of suicide among the patients using the suicide rates of the general Swedish population as a reference. In total, 21 patients committed suicide during follow-up, compared to the predicted 3.6 suicides. Thus, we noted an almost 6-fold increased risk for suicide among ALS patients [SMR 5.8, 95% confidence interval (CI) 3.6-8.8]. Patients who committed suicide were, on average, around 7 years younger at the time of their first period of hospitalization than patients who did not commit suicide. The highest relative risk for suicide was observed within the first year after the patients first period of hospitalization (SMR 11.2, 95% CI 5.8-19.6). After that, the relative risks decreased with time after hospitalization (P-value for trend = 0.006), but remained elevated 3 years later. The relative risks of suicide among ALS patients did not show a clear trend over time in contrast to the decreasing trend of relative risks for suicide among patients with cancer during the same period. Patients with ALS are at excess risk of suicide in Sweden and the relative risk is higher during the earlier stage of the disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a amyotrophic lateral sclerosis
653		a suicide
653		a cohort study
653		a relative risk
653		a MEDICINE
653		a MEDICIN
700	1	a Valdimarsdottir, Unnuru Karolinska Institutet4 aut
700	1	a Furst, Carl Johanu Karolinska Institutet4 aut
700	1	a Hultman, Christinau Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm; Department of Neuroscience, Psychiatry, Ulleråker,Uppsala University,Uppsala4 aut
700	1	a Fall, Katja,d 1971-u Karolinska Institutet4 aut0 (Swepub:oru)kafl
700	1	a Sparen, Paru Karolinska Institutet4 aut
700	1	a Ye, Weiminu Karolinska Institutet4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap4 org
773	0	t Braind Oxford, United Kingdom : Oxford University Press (OUP)g 131, s. 2729-2733q 131<2729-2733x 0006-8950x 1460-2156
856	4	u https://academic.oup.com/brain/article-pdf/131/10/2729/23989575/awn161.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107841
856	4 8	u https://doi.org/10.1093/brain/awn161
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41462
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:117736237

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