WFRF:(Novikova J.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03602naa a2200397 4500 | |
| 001 | oai:DiVA.org:umu-44220 | |
| 003 | SwePub | |
| 008 | 110526s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-442202 URI |
| 024 | 7 | a https://doi.org/10.3109/14653249.2011.5741162 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Novikova, Liudmila Nu Umeå universitet,Anatomi4 aut0 (Swepub:umu)luno0001 |
| 245 | 1 0 | a Neuroprotective and growth-promoting effects of bone marrow stromal cells after cervical spinal cord injury in adult rats |
| 264 | 1 | b Elsevier BV,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Background aims. Bone marrow stromal cells (BMSC) have been shown to provide neuroprotection after transplantation into the injured central nervous system. The present study investigated whether adult rat BMSC differentiated along a Schwann cell lineage could increase production of trophic factors and support neuronal survival and axonal regeneration after transplantation into the injured spinal cord. Methods. After cervical C4 hemi-section, 5-bromo-2-deoxyuridine (BrdU)/green fluorescent protein (GFP)-labeled BMSC were injected into the lateral funiculus at 1 mm rostral and caudal to the lesion site. Spinal cords were analyzed 2-13 weeks after transplantation. Results and Conclusions. Treatment of native BMSC with Schwann cell-differentiating factors significantly increased production of brain-derived neurotrophic factor in vitro. Transplanted undifferentiated and differentiated BMSC remained at the injection sites, and in the trauma zone were often associated with neurofilament-positive fibers and increased levels of vascular endothelial growth factor. BMSC promoted extensive in-growth of serotonin-positive raphaespinal axons and calcitonin gene-related peptide (CGRP)-positive dorsal root sensory axons into the trauma zone, and significantly attenuated astroglial and microglial cell reactions, but induced aberrant sprouting of CGRP-immunoreactive axons in Rexed's lamina III. Differentiated BMSC provided neuroprotection for axotomized rubrospinal neurons and increased the density of rubrospinal axons in the dorsolateral funiculus rostral to the injury site. The present results suggest that BMSC induced along the Schwann cell lineage increase expression of trophic factors and have neuroprotective and growth-promoting effects after spinal cord injury. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a bone marrow | |
| 653 | a mesenchymal stromal cells | |
| 653 | a red nucleus | |
| 653 | a retrograde degeneration | |
| 653 | a spinal cord trauma | |
| 653 | a transplantation | |
| 700 | 1 | a Brohlin, Mariau Umeå universitet,Anatomi4 aut0 (Swepub:umu)mabr0001 |
| 700 | 1 | a Kingham, Paul Ju Umeå universitet,Anatomi4 aut0 (Swepub:umu)paki0006 |
| 700 | 1 | a Novikov, Lev Nu Umeå universitet,Anatomi4 aut0 (Swepub:umu)leno0001 |
| 700 | 1 | a Wiberg, Mikaelu Umeå universitet,Anatomi,Handkirurgi4 aut0 (Swepub:umu)miwi0004 |
| 710 | 2 | a Umeå universitetb Anatomi4 org |
| 773 | 0 | t Cytotherapyd : Elsevier BVg 13:7, s. 873-887q 13:7<873-887x 1465-3249x 1477-2566 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-44220 |
| 856 | 4 8 | u https://doi.org/10.3109/14653249.2011.574116 |
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